基于外泌体的多细胞信号网络和药物载体在调控脑缺血再灌注损伤中的研究进展  

Progress in multicellular signal network and drug carriers based on exo⁃somes in regulation of cerebral ischemia-reperfusion injury

作　　者：周宇 马勇 李斌 柴尔青 ZHOU Yu;MA Yong;LI Bin;CHAI Erqing(First Clinical Medical College,Lanzhou University,Lanzhou 730000,China;Cerebrovascular Disease Center of Gansu Provincial Hospital,Lanzhou University,Gansu Provincial Key Laboratory of Cerebrovascular Diseases,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]甘肃省人民医院脑血管病中心,甘肃省脑血管病重点实验室,甘肃兰州730000

出　　处：《中国病理生理杂志》2023年第12期2280-2287,共8页Chinese Journal of Pathophysiology

基　　金：甘肃省自然科学基金资助项目(No.20JR10RA379)。

摘　　要：脑卒中是全球第二大死因,在多种疾病中卒中的致死率与致残率总和占据第三位,其中主要以缺血性脑卒中为主,占全部卒中事件的62.4%,而在我国脑卒中是第一大致死性疾病和致残性疾病,同时患病率和死亡率在继续增加^([1-2])。近年来,我国各级医院的卒中管理机制在不断完善,溶栓、颅内动脉取栓术、颈动脉支架植入术等再灌注策略更多地应用于脑卒中患者,大幅度地改善了患者的住院期间生存率、降低了年龄标准化死亡率,然而接受再灌注治疗患者的远期预后和生存质量仍较差,造成上述结果的原因除了社会老龄化导致的患者平均年龄升高外,由再灌注策略引发的脑缺血再灌注损伤(cere‐bral ischemia-reperfusion injury,CIRI)也发挥着重要作用^([3-4])。Cerebral stroke has one of the highest incidence,mortality and disability rates worldwide.Although studies have confirmed that reperfusion therapy is an effective strategy for treating stroke patients,the secondary injury of brain tissue caused by reperfusion therapy,which is called cerebral ischaemia reperfusion injury(CIRI),is another medical challenge globally.The microenvironment network constructed by multicellular exosomes plays a regulatory role in the occurrence and development of CIRI.In addition,exosomes have potential value as drug delivery carriers for cerebrovascular diseases due to their stability,the ability to pass through the blood‒brain barrier and other characteristics.This study reviews the research progress on the signal network constructed by multiple cells through exosomes and exosomes as drug carriers in CIRI to provide a reference for research to improve CIRI.

关 键 词：脑缺血再灌注损伤 外泌体 药物载体 脑卒中 细胞信号网络 

分 类 号：R363.2[医药卫生—病理学] R743.31[医药卫生—基础医学]