胆管癌病人循环肿瘤细胞检测的临床价值与意义  

Clinical value and significance of circulating tumor cell detection in patients with cholangiocarcinoma

作　　者：郑博豪 沈盛[1] 南令西 王吉文[1] 锁涛[1] 倪晓凌[1] 刘寒[1] 刘厚宝[1] Zheng Bohao;Shen Sheng;Nan Lingri;Wang Jizwven;Suo Tao;Ni Xiaoling;Liu Han;Liu Houbao(Department of Biliary Surgery,Affiliated Zhongshan Hospital,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院胆道外科,上海200032

出　　处：《腹部外科》2023年第6期468-472,共5页Journal of Abdominal Surgery

基　　金：上海市2021年度“科技创新行动计划”自然科学基金:项目(21ZR1459100);上海市抗癌协会“雏鹰”计划(SHCY-JC-2022169)。

摘　　要：目的 探讨胆管癌病人循环肿瘤细胞(circulation tumor cells, CTC)检测的临床意义。方法 选取2022年6月至2022年12月复旦大学附属中山医院胆道外科收治的胆管癌病人(73例)与同期胆道良性疾病病人(19例)作为研究对象。依托复旦大学附属中山医院检验科平台检测两组病人治疗前CTC水平,并收集病人的临床病理资料。利用受试者工作特征(receiver operating characteristic curve, ROC)曲线分析CTC对于胆管癌的诊断价值以及对于淋巴结转移的预测价值,同时分析CTC水平与胆管癌临床特点之间的关系。结果 胆道良性疾病病人中CTC中位数为0(范围0~4)个/7.5 mL;胆管癌病人中CTC的中位数为1(范围0~12)个/7.5 mL,胆管癌病人中CTC数值明显上升。受试者曲线分析结果提示CTC对于诊断胆管癌[曲线下面积(area under the curve, AUC)为0.601]及预测胆管癌淋巴结转移(AUC:0.640)及远处转移(AUC:0.689)有着一定的价值。外周血CTC是胆管癌病人的潜在生物标志物。结论 外周血CTC是胆管癌潜在的诊断标志物,值得进一步进行探索。Objective To explore the clinical significance of CTC(circulation tumor cells)in cholangiocarcinoma.Methods From June 2022 to December 2022,patients with cholangiocarcinoma(n=73)and benign biliary disease(n=19)were selected as research subjects.Through an institutional laboratory platform,the pre-treatment levels of CTC were detected and the relevant clinicopathological data collected.Receiver operating characteristic(ROC)curves were plotted for examining the diagnostic value of CTC for cholangiocarcinoma and the predictive value for lymph node metastasis.And relationship between level of CTC and clinical characteristics of cholangiocarcinoma was analyzed.Results As compared with benign diseases,the detection rate and number of peripheral blood CTCs were significantly greater in patients with cholangiocarcinoma.The results of ROC curve analysis implied that CTC had some value in diagnosing biliary tract cancer and predicting lymph node metastasis and distant metastasis of biliary tract cancer.Conclusion Peripheral blood CTCs are potential diagnostic markers for cholangiocarcinoma. Further explorations are required.

关 键 词：胆管癌 循环肿瘤细胞 诊断 肿瘤转移 

分 类 号：R735.8[医药卫生—肿瘤]