肿瘤微环境对胃癌化疗耐药的影响  

Effect of tumor microenvironment on chemotherapy resistance in gastric cancer

作　　者：高田宇 樊勇[1] 高远飞 邓成伍 张栋岩 黄伟芃 王琛[1] GAO Tianyu;FAN Yong;GAO Yuanfei;DENG Chengwu;ZHANG Dongyan;HUANG Weipeng;WANG Chen(Department of General Surgery,Second Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第二医院普通外科,兰州730000

出　　处：《生命的化学》2023年第10期1591-1598,共8页Chemistry of Life

基　　金：甘肃省科技重大专项计划项目(19ZD2WA001);兰州大学第二医院萃英科技创新计划项目(CY2022-BJ-06,CY2021-M5-A17)。

摘　　要：胃癌是一种消化道高发恶性肿瘤,化疗耐药是其相关性死亡的主要原因之一。肿瘤微环境(tumor microenvironment,TME)通过各种途径与机制促进胃癌化疗耐药,因而TME可能是评估肿瘤发展方向和克服治疗耐药的关键。鉴于治疗胃癌化疗耐药缺乏有效的临床方案,本文综述了TME中的细胞成分、非细胞成分与胃癌细胞化疗耐药之间的联系,以及TME中主要成分与化疗耐药相关联的生物标志物和治疗靶点。此外,本文进一步讨论了TME中不同细胞促进胃癌化疗抵抗的机制,总结了潜在的调节因子与药物,旨在为临床解决胃癌化疗耐药性提供新的角度,并为胃癌防治提供新思路。Gastric cancer is a kind of malignant tumor with high incidence of digestive tract.Chemotherapy resistance is one of the main causes of death.Tumor microenvironment(TME)promotes chemotherapy resistance in gastric cancer through various pathways and mechanisms,so TME may be the key to evaluate tumor development direction and overcome therapeutic resistance.In view of the lack of effective clinical protocols for the treatment of chemotherapy resistance in gastric cancer,this paper reviewed the relationship between cellular and non-cellular components of TME and chemotherapy resistance in gastric cancer cells,as well as the biomarkers and therapeutic targets associated with major components of TME and chemotherapy resistance.In addition,this paper further discussed the mechanism of different cells in TME promoting chemotherapy resistance in gastric cancer,and summarized the potential regulatory factors and drugs,aiming to provide a new perspective for the clinical solution of chemotherapy resistance in gastric cancer,and provide new ideas for the prevention and treatment of gastric cancer.

关 键 词：胃癌 肿瘤微环境 化疗 耐药 

分 类 号：R735.2[医药卫生—肿瘤]