硫酸镁治疗老年脑出血合并低镁血症患者的疗效及对患者ET、NO水平的影响  

Efficacy of Magnesium Sulfate in Treating Elderly Patients with Cerebral Hemorrhage Complicated with Hypomagnesemia and its Effect on ET and NO Levels

作　　者：李举军 王永刚 吉元超 胡进斌 LI Jujun;WANG Yonggang;JI Yuanchao(Xunyang City Traditional Chinese Medicine Hospital,Ankang Shaanxi 725700)

机构地区：[1]陕西省旬阳市中医院神经外科,陕西安康725700 [2]陕西省旬阳市中医院创伤外科,陕西安康725700

出　　处：《医学临床研究》2023年第11期1700-1702,1706,共4页Journal of Clinical Research

摘　　要：【目的】探讨硫酸镁治疗老年脑出血合并低镁血症患者的疗效及对内皮素(ET)、一氧化氮(NO)水平的影响。【方法】本院收治的93例脑出血合并低镁血症患者,随机分为观察组(47例)和对照组(46例)。两组均接受降颅压、止血、吸氧等常规对症治疗,对照组静脉滴注醒脑静,观察组在对照组基础上联合硫酸镁治疗。比较两组临床疗效,治疗前后血清镁、ET、NO水平及神经功能缺损量表(NIHSS)和日常生活活动量表(ADL)评分。【结果】观察组治疗总有效率高于对照组(P<0.05);治疗后,两组血清镁水平较治疗前提高,ET、NO水平降低(P<0.05),且观察组血清镁水平高于对照组,ET、NO水平低于对照组(P<0.05);治疗后1周和2周,两组ADL评分呈上升趋势,NIHSS评分呈下降趋势(P<0.05);且观察组治疗后1周和2周ADL评分高于对照组,NIHSS评分低于对照组(P<0.05)。【结论】硫酸镁治疗老年脑出血合并低镁血症的疗效较好,有利于提高血清镁水平,降低NO、ET水平,促进患者神经功能恢复,具有较好的应用价值。【Objective】To investigate the efficacy of magnesium sulfate in treating elderly patients with cerebral hemorrhage complicated with hypomagnesemia and its effects on endothelin(ET)and nitric oxide(NO)levels.【Methods】A total of 93 patients with cerebral hemorrhage complicated with hypomagnesemia admitted to our hospital were randomly divided into the observation group(n=47)and the control group(n=46).Both groups received conventional symptomatic treatments such as intracranial pressure reduction,hemostasis,and oxygen inhalation.The control group was intravenously dripped with Xingnaojing,while the observation group received magnesium sulfate treatment on top of the control group's treatment.The clinical efficacy,serum magnesium,ET,NO levels,and scores from the National Institutes of Health Stroke Scale(NIHSS)and activities of daily living(ADL)were compared before and after treatment.【Results】The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the serum magnesium levels in both groups increased compared to before treatment,while ET and NO levels decreased(P<0.05).The observation group had higher post-treatment serum magnesium levels and lower post-treatment ET and NO levels than the control group(P<0.05).One and two weeks post-treatment,the ADL scores of both groups showed an upward trend,and the NIHSS scores showed a downward trend(P<0.05).Moreover,the post-treatment ADL score of the observation group was higher and the post-treatment NIHSS score was lower in the observation group than those in the control group(P<0.05).【Conclusion】Magnesium sulfate has a good therapeutic effect on elderly patients with cerebral hemorrhage complicated with hypomagnesemia.It helps to increase serum magnesium,reduce NO and ET levels,promote the recovery of neurological function,and has significant application value.

关 键 词：脑出血 硫酸镁/治疗应用 一氧化氮/血液 内皮缩血管肽类/血液 

分 类 号：R743.34[医药卫生—神经病学与精神病学]