氢氧化钙糊剂联合米诺环素治疗根尖周炎患者的临床疗效  

Clinical Efficacy of Calcium Hydroxide Paste Combined with Minocycline in the Treatment of Patients with Periapical Periodontitis

作　　者：杨筱 陈萌 董建伟 YANG Xiao;CHEN Meng;DONG Jianwei(Department of Stomatology,Shangluo Central Hospital,Shangluo Shaanxi 726000)

机构地区：[1]商洛市中心医院口腔科,陕西商洛726000

出　　处：《医学临床研究》2023年第11期1723-1726,共4页Journal of Clinical Research

摘　　要：【目的】探讨氢氧化钙糊剂联合米诺环素治疗慢性根尖周炎患者的临床疗效。【方法】选取本院确诊的210例慢性根尖周炎患者,按照就诊顺序分为联合组(采用氢氧化钙糊剂联合米诺环素治疗)、氢氧化钙组(采用氢氧化钙组糊剂治疗)、米诺环素组(采用米诺环素治疗),每组70例。比较三组患者临床疗效及治疗前后的临床症状评分、龈沟液中炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)]水平。【结果】治疗前,联合组、氢氧化钙组、米诺环素组牙龈红肿、疼痛、扣痛症状评分比较,差异无统计学意义(P>0.05);治疗后,三组患者牙龈红肿、疼痛、扣痛症状评分较本组治疗前均显著降低(P<0.05),且联合组上述指标低于氢氧化钙组、米诺环素组(P<0.05)。治疗前,联合组、氢氧化钙组、米诺环素组的龈沟液中TNF-α、IL-1β、IL-6水平比较,差异无统计学意义(P>0.05);治疗后,三组患者的龈沟液中TNF-α、IL-1β、IL-6水平较本组治疗前均显著降低(P<0.05),且联合组低于氢氧化钙组、米诺环素组(P<0.05)。三组患者临床疗效比较,差异具有统计学意义(P<0.05),且联合组临床疗效优于氢氧化钙组、米诺环素组。【结论】氢氧化钙糊剂联合米诺环素治疗慢性根尖周炎可有效缓解患者的临床症状,减轻炎症反应,提高临床治疗效果。【Objective】To investigate the clinical efficacy of calcium hydroxide paste combined with minocycline in the treatment of patients with periapical periodontitis.【Methods】A total of 210 patients with chronic periapical periodontitis diagnosed in our hospital were selected and divided into a combined group(treated with calcium hydroxide paste combined with minocycline),a calcium hydroxide group(treated with calcium hydroxide paste),and a minocycline group(treated with minocycline),with 70 cases in each group.The clinical efficacy and the clinical symptom scores before and after treatment,as well as the inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),interleukin-6(IL-6)]in gingival crevicular fluid were compared among the three groups.【Results】Before treatment,there was no significant difference in the symptom scores of gingival redness,pain,and tenderness among the combined group,calcium hydroxide group,and minocycline group(P>0.05).After treatment,the symptom scores of gingival redness,pain,and tenderness in all three groups were significantly lower than those before treatment(P<0.05),and the combined group had lower scores than the calcium hydroxide group and the minocycline group(P<0.05).Before treatment,there was no significant difference in the levels of TNF-α,IL-1β,and IL-6 in gingival crevicular fluid among the combined group,calcium hydroxide group,and minocycline group(P>0.05).After treatment,the levels of TNF-α,IL-1β,and IL-6 in gingival crevicular fluid in all three groups were significantly lower than those before treatment(P<0.05),and the combined group had lower levels than the calcium hydroxide group and the minocycline group(P<0.05).The clinical efficacy among the three groups was compared,and the difference was statistically significant(P<0.05),and the combined group had better clinical efficacy than the calcium hydroxide group and the minocycline group.【Conclusion】Combined treatment with calcium hydroxide paste and minocycline can effectively allevi

关 键 词：根尖周炎/药物疗法 羟化钙/药理学 米诺环素/药理学 

分 类 号：R781.3[医药卫生—口腔医学]