中老年上消化道肿瘤患者合并心血管代谢性疾病的影响因素分析  

Influencing factors of cardiometabolic diseases in middle-aged and elderly patients with upper gastrointestinal cancer

作　　者：杨帆[1] 肖凡凱 李平 郭森 赵洛沙[1] 韩战营[1] YANG Fan;XIAO Fankai;LI Ping;GUO Sen;ZHAO Luosha;HAN Zhanying(Department of Cardiology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052;Department of Oncology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052;Department of Internal Medicine,Henan Medical College,Zhengzhou 451191)

机构地区：[1]郑州大学第一附属医院心内科,郑州450052 [2]郑州大学第一附属医院肿瘤科,郑州450052 [3]河南医学高等专科学校内科教研室,郑州451191

出　　处：《郑州大学学报（医学版）》2023年第6期860-863,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省医学科技攻关计划项目(2018020537);河南省科技攻关项目(212102310797)。

摘　　要：目的:探讨中老年上消化道肿瘤患者合并心血管代谢性疾病(CMD)冠心病、高血压、脑卒中、糖尿病的影响因素。方法:回顾性分析中老年上消化道肿瘤患者4 116例的临床资料。患者中合并CMD 1 399例,未合并2 717例。比较两组患者的临床特征,采用Logistic回归分析中老年上消化道肿瘤患者合并CMD的影响因素。结果:中老年上消化道肿瘤男性患者合并CMD的比例高于女性;合并CMD患者的年龄、心率、甘油三酯和肌酐水平高于未合并CMD者;HDL-C水平低于未合并CMD者(P<0.05)。Logistic回归分析显示年龄65~97岁是上消化道肿瘤合并CMD的危险因素(OR=2.389,95%CI为2.092~2.727)。结论:中老年上消化道肿瘤患者合并CMD的比例较高,65~97岁的患者更易发生。Aim:To explore the influencing factors of cardiometabolic diseases(CMD) such as coronary heart disease,hypertension,stroke,and diabetes in middle-aged and elderly patients with upper gastrointestinal cancer.Methods:A retrospective analysis of clinical data from 4 116 cases of middle-aged and elderly patients with upper gastrointestinal cancer was conducted.There were 1 399 patients with CMD and 2 717 patients without CMD.Clinical characteristics of the 2 groups were compared,and Logistic regression analysis was used to identify the influencing factors for CMD in middle-aged and elderly patients with upper gastrointestinal cancer.Results:The proportion of males with CMD was higher than females among middle-aged and elderly patients with upper gastrointestinal cancer;patients with CMD had higher age,heart rate,triglyceride,and creatinine levels,and lower HDL-C level than those without CMD(P<0.05).Logistic regression analysis showed that age of 65-97 years was a risk factor for upper gastrointestinal cancer complicated with CMD(OR=2.389,95%CI:2.092-2.727).Conclusion:The proportion of middle-aged and elderly patients with upper gastrointestinal cancer combined with CMD is relatively high,especially for patients aged 65-97 years.

关 键 词：上消化道肿瘤 心血管代谢性疾病 危险因素 

分 类 号：R735[医药卫生—肿瘤] R54[医药卫生—临床医学]