Flattening the biological age curve by improving metabolic health:to taurine or not to taurine,that’s the question  

作　　者：Kwok M.Ho Anna Lee William Wu Matthew T.V.Chan Lowell Ling Jeffrey Lipman Jason Roberts Edward Litton Gavin M.Joynt Martin Wong 

机构地区：[1]Department of Intensive Care Medicine,Fiona Stanley Hospital,Perth,Australia [2]Medical School,The University of Western Australia,Perth,Australia [3]School of Veterinary&Life Sciences,Murdoch University,Perth,Australia [4]Department of Anaesthesia&Intensive Care,Prince of Wales Hospital,Chinese University of Hong Kong,Hong Kong,China [5]Jamieson Trauma Institute,Royal Brisbane and Women’s Hospital,Brisbane,Queensland,Australia [6]Division of Anaesthesiology Critical Care Emergency and Pain Medicine,Nîmes University Hospital,University of Montpellier,Nîmes,France [7]University of Queensland Centre for Clinical Research,Faculty of Medicine,The University of Queensland,Brisbane,Australia [8]Herston Infectious Diseases Institute(HeIDI),Metro North Health,Brisbane,Australia [9]Departments of Pharmacy and Intensive Care Medicine,Royal Brisbane and Women’s Hospital,Brisbane,Australia [10]JC School of Public Health and Primary Care,Centre for Health Education and Health Promotion,Chinese University of Hong Kong,Hong Kong,China [11]School of Public Health,Peking University,Beijing,China [12]School of Public Health,Fudan University,Shanghai,China

出　　处：《Journal of Geriatric Cardiology》2023年第11期813-823,共11页老年心脏病学杂志（英文版）

摘　　要：The aging population is an important issue around the world especially in developed countries.Although med-ical advances have substantially extended life span,the same cannot be said for the duration of health span.We are seeing in-creasing numbers of elderly people who are frail and/or have multiple chronic conditions;all of these can affect the quality of life of the elderly population as well as increase the burden on the healthcare system.Aging is mechanistically related to common medical conditions such as diabetes mellitus,ischemic heart disease,cognitive decline,and frailty.A recently accepted concept termed‘Accelerated Biological Aging’can be diagnosed when a person’s biological age—as measured by biomarkers of DNA methylation—is older than their corresponding chronological age.Taurine,a conditionally essential amino acid,has received much attention in the past few years.A substantial number of animal studies have provided a strong scientific foundation sug-gesting that this amino acid can improve cellular and metabolic health,including blood glucose control,so much that it has been labelled one of the‘longevity amino acids’.In this review article,we propose the rationale that an adequately powered random-ized-controlled-trial(RCT)is needed to confirm whether taurine can meaningfully improve metabolic and microbiome health,and biological age.This trial should incorporate certain elements in order to provide the much-needed evidence to guide doctors,and also the community at large,to determine whether this promising and inexpensive amino acid is useful in improving human metabolic health.

关 键 词：RATIONAL meaningful TAURINE 

分 类 号：R151[医药卫生—营养与食品卫生学]