血流导向装置在颅内前循环破裂动脉瘤中的应用效果  

Application effect of blood flow guide device in ruptured aneurysms in anterior intracranial circulation

作　　者：杨巧钰 罗针 赵小燕 李昌泰 杨威 YANG Qiaoyu;LUO Zhen;ZHAO Xiaoyan;LI Changtai;YANG Wei(West China Hospital,Sichuan University/West China School of Nursing,Sichuan University,Chengdu 610041,China;Hospital of Chengdu Office of People’s Government of Tibetan Autonomous Region,Chengdu 610041,China)

机构地区：[1]四川大学华西医院四川大学华西护理学院,四川成都610041 [2]西藏自治区人民政府驻成都办事处医院,四川成都610041

出　　处：《中国实用神经疾病杂志》2024年第1期9-14,共6页Chinese Journal of Practical Nervous Diseases

基　　金：四川大学华西护理学科发展专项基金重点项目(编号:HXHL19002)。

摘　　要：目的分析血流导向装置在颅内前循环破裂动脉瘤中的应用效果。方法选取2019-10—2022-10华西医院收治的84例颅内前循环破裂动脉瘤患者为研究对象,采用随机数字表法分为观察组42例与对照组42例。对照组患者采用开颅夹闭术治疗,观察组患者采用血流导向装置治疗,随访6个月,比较2组患者手术情况、恢复效果、相关血清学指标以及并发症发生率。结果观察组患者手术结束时OKM分级[(3.82±0.05)分]、术后6个月GOS评分[(4.23±0.45)分]、术后24 h GCS评分[(15.18±2.79)分]高于对照组[分别为(3.67±0.08)分、(3.71±0.58)分、(12.36±2.54)分],住院时间[(17.21±3.87)d]短于对照组[(24.36±5.25)d],术后6个月血清Caspase-3[(157.38±45.15)μg/L]、MMP-9水平[(12.83±2.41)μg/L]及总并发症发生率(9.52%)均低于对照组[分别为(294.76±58.43)μg/L、(18.62±3.58)μg/L、26.19%],差异均有统计学意义(P<0.05)。结论颅内前循环破裂动脉瘤患者应用血流导向装置能够显著提升栓塞效果,改善血清学指标和预后,缩短住院时间,降低并发症发生率。Objective To analyze the application effect of blood flow guide device in ruptured aneurysm of anterior intracranial circulation.Methods From October 2019 to October 2022,84 patients with ruptured aneurysms of anterior intracranial circulation admitted to the West China Hospital were selected as the study objects,which were divided into observation group(42 cases)and control group(42 cases)according to the random number table method.Patients in the control group were treated by craniotomy clipping,and patients in the observation group were treated by blood flow guide device with following-up for 6 months.The surgical condition,recovery effect,relevant serological indicators and complication rate between the two groups were compared.Results At the end of surgery,the OKM grade((3.82±0.05)points),GOS score at 6-month((4.23±0.45)points),GCS score at 24-hour((15.18±2.79)points)were higher than the control group((3.67±0.08)points,(3.71±0.58)points,(12.36±2.54)points).The length of hospital stay((17.21±3.87)d)was shorter than that of the control group((24.36±5.25)d).The serum Caspase-3((157.38±45.15)μg/L),MMP-9((12.83±2.41)μg/L)and overall complication rate(9.52%)were lower than the control group((294.76±58.43)μg/L,(18.62±3.58)μg/L,26.19%,respectively).The differences were all statistically significant(P<0.05).Conclusion The application of blood flow guide device in patients with ruptured intracranial circulation aneurysm can significantly improve the embolization effect,improve the serological index and prognosis level,shorten the length of hospital stay,and reduce the incidence of complications.

关 键 词：动脉瘤 前循环 破裂动脉瘤 动脉瘤栓塞术 血流导向装置 开颅夹闭术 

分 类 号：R743[医药卫生—神经病学与精神病学]