腹侧被盖区多巴胺能神经元参与调控焦虑样行为研究进展  

Research progress on the involvement of dopaminergic neurons in the ventral tegmental area in the regula⁃tion of anxiety-like behavior

作　　者：张逸 杨璐 彭劲涛 蒋宇婷 孙丰蛟 崔明湖[1] ZHANG Yi;YANG Lu;PENG Jintao;JIANG Yuting;SUN Fengjiao;CUI Minghu(Binzhou medical university hospital,Binzhou 256603,China)

机构地区：[1]滨州医学院附属医院心理科,滨州256603 [2]滨州医学院附属医院医学研究中心

出　　处：《中国神经精神疾病杂志》2023年第9期565-569,共5页Chinese Journal of Nervous and Mental Diseases

基　　金：国家自然科学基金(编号:82101584)。

摘　　要：焦虑障碍、多巴胺能神经元和腹侧被盖区(ventral tegmental area,VTA)三者联系密切,VTA多巴胺能神经元在调控焦虑中发挥重要作用。动物研究结果表明VTA多巴胺能神经元参与多条神经投射环路,这些环路可分别对生理或病理状态下的焦虑样行为起调控作用;多巴胺是VTA主要神经递质,可通过多巴胺D_1和D_2受体调控焦虑;此外,VTA中的谷氨酸、γ-氨基丁酸、乙酰胆碱在调控焦虑中也起到直接或间接作用。临床影像学研究发现焦虑障碍组多巴胺能VTA结构完整性低于健康对照组。目前,关于VTA多巴胺能神经元参与调控焦虑样行为的研究处于高速发展中,更深入地探索将进一步阐明焦虑障碍的发病机制,为焦虑障碍的防治提供新思路。Anxiety disorders,dopaminergic neurons and ventral tegmental area(VTA)are related closely.VTA dopaminergic neurons play an important role in the regulation of anxiety.Numerous research results in animals indicated that the VTA dopaminergic neurons,involving in multiple neural pathways,respectively regulate anxiety-like behavior in physiological or pathological condition.Dopamine,the main neurotransmitters in VTA regulates anxiety through dopamine D1 and D2 receptors.In addition,the VTA glutamate,GABA and acetylcholine also play directly or indirectly roles in regulating anxiety.The clinical imaging research showed that the integrity of dopaminergic VTA structural of anxiety disorder group is lower than healthy control.Current researches of VTA dopamine neurons involving in the regulation of anxiety-like behavior is developing at a high speed and deserving further exploration,which will further elucidate the pathogenesis and provide new ideas for prevention and treatment of anxiety disorders.

关 键 词：焦虑 腹侧被盖区 多巴胺 神经环路 神经递质 神经生理学 神经病理学 

分 类 号：R749.7[医药卫生—神经病学与精神病学]