十分之一剂量^(18)F-FDG全身PET/CT肿瘤显像可行性的临床研究  

Feasibility of one-tenth dose ^(18)F-FDG total-body PET/CT in patients with malignant tumors

作　　者：高华萍 林禹 谭辉 郑哲 石洪成 Gao Huaping;Lin Yu;Tan Hui;Zheng Zhe;Shi Hongcheng(Shanghai Institution of Medical Imaging Department of Nuclear Medicine,Zhongshan Hospital,Fudan University Nuclear Medicine Institute of Fudan University,Shanghai 200032,China)

机构地区：[1]上海市影像医学研究所、复旦大学附属中山医院核医学科、复旦大学核医学研究所,上海200032

出　　处：《中华核医学与分子影像杂志》2023年第12期707-712,共6页Chinese Journal of Nuclear Medicine and Molecular Imaging

摘　　要：目的探讨1/10剂量^(18)F-FDG全身PET/CT(TB PET/CT)肿瘤显像的可行性。方法回顾性分析2020年4月至2022年9月于复旦大学附属中山医院行1/10剂量(按体质量0.37 MBq/kg)^(18)F-FDG TB PET/CT的34例初诊肿瘤患者[男30例、女4例,年龄(64.0±1.6)岁]的临床及影像资料,将全身PET原始数据分别重建成15 min和起始2 min的PET图像(G15和G2);另外,按照病理类型匹配34例行全剂量(按体质量3.70 MBq/kg)^(18)F-FDG常规数字化PET/CT(C PET/CT)的初诊肿瘤患者[男27例、女7例,年龄(63.3±2.1)岁],其PET扫描速度为每个床位2~3 min。比较组间信噪比(SNR)差异,以及对经手术病理证实病灶的检出率的组间差异。采用χ^(2)检验、两独立样本t检验、Mann-WhitneyU检验、Wilcoxon秩和检验等进行数据比较。结果TB PET/CT组和C PET/CT组在性别、年龄、体质量指数(BMI)、血糖水平、注射后等待时间等方面差异均无统计学意义(χ^(2)=0.98,t值:0.08、-1.05,z值:0.68、0.41,均P>0.05)。G15组、C PET/CT组和G2组SNR依次递减,分别为16.0(11.3,20.0)、10.5(8.2,13.5)和8.4±0.3,两两比较差异均有统计学意义(z值:5.09、3.31、-4.24,均P<0.05)。对于原发病灶加肝转移灶的检出率,G15、G2组均为100%(37/37),C PET/CT也为100%(36/36)。G15、G2组的淋巴结转移灶检出率均为10/15,高于C PET/CT的64.4%(29/45),差异有统计学意义(χ^(2)=62.03,P=0.002)。结论1/10剂量^(18)F-FDG TB PET/CT显像2 min采集在临床实践中具有可行性。Objective To explore the feasibility of one-tenth dose ^(18)F-FDG total-body PET/CT(TB PET/CT)in patients with malignant tumors.Methods A retrospective analysis was carried out on 34 preliminarily diagnosed cancer patients(30 males,4 females,age(64.0±1.6)years)who underwent one-tenth dose(0.37 MBq/kg)^(18)F-FDG TB PET/CT examination between April 2020 and September 2022 in Zhongshan Hospital,Fudan University.The raw data were reconstructed into 15 min and initial 2 min PET images(G15 and G2,respectively).A matched cohort of 34 preliminarily diagnosed malignant tumor patients(27 males,7 females,age(63.3±2.1)years)undergoing full dose(3.70 MBq/kg)^(18)F-FDG conventional digital PET/CT(C PET/CT)examination with a PET scan rate of 2-3 min/bed position,were analyzed in line with the same pathological types.Signal-to-noise ratios(SNR)of G15,G2 and C PET/CT groups were compared,and based on the pathological results,the detection rates of those 3 groups for lesions were also compared.Theχ^(2) test,independent sample t-test,Mann-Whitney U test,and Wilcoxon rank sum test were used for data analysis.Results The significant differences in gender,age,body mass index(BMI),blood sugar level and postinjection waiting time between TB PET/CT group and C PET/CT group were not found(χ^(2)=0.98,t values:0.08,-1.05,z values:0.68,0.41,all P>0.05).The SNR,from G15 to C PET and G2 groups,decreased gradually,which were 16.0(11.3,20.0),10.5(8.2,13.5)and 8.4±0.3 respectively(z values:5.09,3.31,-4.24,all P<0.05).All primary lesions and hepatic metastases were detected by G15 and G2 imaging(100%,37/37)as well as by C PET/CT(100%,36/36).The detection rates for lymph node metastasis lesions were 10/15 in the G2/G15 groups,which were higher than the detection rate in the C PET/CT group(64.4%(29/45);χ^(2)=62.03,P=0.002).Conclusion One-tenth dose ^(18)F-FDG TB PET/CT with a 2-minute acquisition is feasibility in the clinical practice.

关 键 词：肿瘤 正电子发射断层显像术 体层摄影术 X线计算机 氟脱氧葡萄糖F18 低剂量 

分 类 号：R730.44[医药卫生—肿瘤]