反应工程法在研究中药喷雾干燥过程中单液滴干燥行为的应用展望  

Application prospect of reaction engineering approach in studying drying behavior of single droplet during spray drying of traditional Chinese medicine

作　　者：唐培渝 王学成 王晓辉 徐柳风 李远辉 伍振峰 杨明 TANG Pei-yu;WANG Xue-cheng;WANG Xiao-hui;XU Liu-feng;LI Yuan-hui;WU Zhen-feng;YANG Ming(Key Laboratory of Modern Preparation of Chinese Medicine,Ministry of Education,Jiangxi University of Chinese Medicine,Nanchang 330004,China)

机构地区：[1]江西中医药大学,现代中药制剂教育部重点实验室,江西南昌330004

出　　处：《中国中药杂志》2023年第22期6011-6020,共10页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(82003952);江西中医药大学科研基金项目(2022WBZR006);中央引导地方科技发展资金项目(2022ZDD03085)。

摘　　要：喷雾干燥技术是中药制剂生产最常用单元操作之一,具有干燥时间短、产品品质均一等优势。然而,由于中药提取物具有黏度大、吸湿性强、流动性差等性质,从药企生产的宏观角度解决喷雾干燥尚存在的粘壁、结块等问题空间非常有限。因此,从单液滴蒸发行为的微观角度研究喷雾干燥进而优化工艺成为趋势。基于反应工程法的单液滴干燥系统作为一种新的液滴研究方法,通过采集中药单颗液滴在干燥过程的参数数据,采用反应工程法(reaction engineering approach,REA)对数据处理建立预测模型,是研究中药喷雾干燥机制的重要手段。因此该文总结分析了各类单液滴系统的特点、 REA在单液滴干燥系统中的应用,及其在中药喷雾干燥领域对优化工艺、预测干燥状态、缩短研发周期的重要意义。展望了该方法的前景,包括新参数、新成像技术的引入等,以期为该方法在中药喷雾干燥领域的深入研究提供参考。Spray drying technology is one of the most commonly used unit operations in the production of traditional Chinese medicine(TCM) preparations,offering advantages such as short drying time and uniform product quality.However,due to the properties of TCM extracts,such as high viscosity,strong hygroscopicity,and poor flowability,there is limited scope to solve the problems of wall adhesion and clumping in spray drying from the macroscopic perspective of pharmaceutical production.Therefore,it has become a trend to study and optimize the spray drying process from the microscopic point of view by investigating single droplet evaporation behavior.Based on the reaction engineering approach(REA),the single droplet drying system,as a novel method for studying droplets,collects parameter data on individual TCM droplets during the drying process and uses the REA to process the data and establish predictive models.This approach is crucial for understanding the mechanism of TCM spray drying.This paper summarized and analyzed the cha-racteristics of various single droplet systems,the application of REA in single droplet drying systems,and its significance in optimizing the process,predicting drying states,and shortening the development cycle in the field of TCM spray drying,and looked ahead to the prospects of this method,including the introduction of new parameters and imaging techniques,aiming to provide a reference for further research in the field of TCM spray drying.

关 键 词：中药 喷雾干燥 单液滴干燥 反应工程法 工艺优化 

分 类 号：R283[医药卫生—中药学]