Magnetic resonance-guided focused ultrasound for essential tremor:a prospective,single center,single-arm study  

作　　者：Rui Zong Xuemei Li Chunyu Yin Jianfeng He Dekang Zhang Xiangbing Bian Lichao Huang Jiayou Zhou Zhipei Ling Lin Ma Xin Lou Longsheng Pan Xinguang Yu 

机构地区：[1]Seniro Department of Neurosurgery,The First Medical Center of the PLA General Hospital,Beijing,China [2]Clinics of Cadre,Department of Outpatient,The First Medical Center of the PLA General Hospital,Beijing,China [3]Department of Radiology,The First Medical Center of the PLA General Hospital,Beijing,China

出　　处：《Neural Regeneration Research》2024年第9期2075-2080,共6页中国神经再生研究（英文版）

基　　金：sponsored by Insightec Co.Ltd.(Israel);China National Clinical Research Center for Geriatrics,No.NCRCG-PLAGH-2019005 (to LP)

摘　　要：The safety and effectiveness of magnetic resonance-guided focused ultrasound thalamotomy has been broadly established and validated for the treatment of essential tremor.In 2018,the first magnetic resonance-guided focused ultrasound system in Chinese mainland was installed at the First Medical Center of the PLA General Hospital.This prospective,single center,open-label,single-arm study was part of a worldwide prospective multicenter clinical trial(ClinicalTrials.gov Identifier:NCT03253991)conducted to confirm the safety and efficacy of magnetic resonance-guided focused ultrasound for treating essential tremor in the local population.From 2019 to 2020,10 patients with medication refractory essential tremor were recruited into this open-label,single arm study.The treatment efficacy was determined using the Clinical Rating Scale for Tremor.Safety was evaluated according to the incidence and severity of adverse events.All of the subjects underwent a unilateral thalamotomy targeting the ventral intermediate nucleus.At the baseline assessment,the estimated marginal mean of the Clinical Rating Scale for Tremor total score was 58.3±3.6,and this improved after treatment to 23.1±6.4 at a 12-month follow-up assessment.A total of 50 adverse events were recorded,and 2 were defined as serious.The most common intraoperative adverse events were nausea and headache.The most frequent postoperative adverse events were paresthesia and equilibrium disorder.Most of the adverse events were mild and usually disappeared within a few days.Our findings suggest that magnetic resonance-guided focused ultrasound for the treatment of essential tremor is effective,with a good safety profile,for patients in Chinese mainland.

关 键 词：efficacy essential tremor magnetic resonance-guided focused ultrasound(MRgFUS) movement disorder safety stereotactic therapy THALAMOTOMY ventral intermediate nucleus 

分 类 号：R742[医药卫生—神经病学与精神病学]