Towards system genetics analysis of head and neck squamous cell carcinoma using the mouse model,cellular platform,and clinical human data  

作　　者：Osayd Zohud Iqbal M.Lone Aysar Nashef Fuad A.Iraqi 

机构地区：[1]Department of Clinical Microbiology and Immunology,Sackler Faculty of Medicine,Tel-Aviv University,Tel Aviv,Israel [2]Department of Oral and Maxillofacial Surgery,Baruch Padeh Medical Center,Poriya,Israel [3]Azrieli Faculty of Medicine,Bar-Ilan University,Ramat Gan,Israel

出　　处：《Animal Models and Experimental Medicine》2023年第6期537-558,共22页动物模型与实验医学（英文）

基　　金：supported by a core fund from Tel Aviv University and the Department of Oral and Maxillofacial Surgery,Baruch Padeh Medical Center,Poriya,Israel。

摘　　要：Head and neck squamous cell cancer(HNSCC)is a leading global malignancy.Every year,More than 830000 people are diagnosed with HNSCC globally,with more than 430000 fatalities.HNSCC is a deadly diverse malignancy with many tumor locations and biological characteristics.It originates from the squamous epithelium of the oral cavity,oropharynx,nasopharynx,larynx,and hypopharynx.The most frequently impacted regions are the tongue and larynx.Previous investigations have demonstrated the critical role of host genetic susceptibility in the progression of HNSCC.Despite the advances in our knowledge,the improved survival rate of HNSCC patients over the last 40 years has been limited.Failure to identify the molecular origins of development of HNSCC and the genetic basis of the disease and its biological heterogeneity impedes the development of new therapeutic methods.These results indicate a need to identify more genetic factors underlying this complex disease,which can be better used in early detection and prevention strategies.The lack of reliable animal models to investigate the underlying molecular processes is one of the most significant barriers to understanding HNSCC tumors.In this report,we explore and discuss potential research prospects utilizing the Collaborative Cross mouse model and crossing it to mice carrying single or double knockout genes(e.g.Smad 4 and P53 genes)to identify genetic factors affecting the development of this complex disease using genome-wide association studies,epigenetics,micro RNA,long noncoding RNA,lnc RNA,histone modifications,methylation,phosphorylation,and proteomics.

关 键 词：animal models Collaborative Cross mice GENOMICS head and neck squamous cell cancinoma host genetic susceptibility 

分 类 号：R739.91[医药卫生—肿瘤] R-332[医药卫生—临床医学]