5-羟色胺相关基因与偏头痛的研究进展  

Research Progress of Genes Related to 5-Hydroxytryptamine and Migraine

作　　者：黄桂娇 邵小娇 高珊 关欣颖 HUANG Guijiao;SHAO Xiaojiao;GAO Shan;GUAN Xinying(Jinzhou Medical University,Jinzhou 121001,China;Kangda College of Nanjing Medical University,Lianyungang 222000,China;Department of Neurology,Affiliated Lianyungang Hospital of Xuzhou Medical University,Lianyungang 222000,China;Department of Neurology,the First Affiliated Hospital of Kangda College of Nanjing Medical University,Lianyungang 222000,China)

机构地区：[1]锦州医科大学,辽宁锦州121001 [2]南京医科大学康达学院,江苏连云港222000 [3]徐州医科大学附属连云港医院神经内科,江苏连云港222000 [4]南京医科大学康达学院第一附属医院神经内科,江苏连云港222000

出　　处：《医学综述》2023年第23期5187-5191,5196,共6页Medical Recapitulate

基　　金：国家自然科学基金(82001171);连云港市科技项目(SF2114)。

摘　　要：偏头痛是一种常见的慢性神经血管性疾病,严重影响人们的生活,目前发病机制尚不明确。偏头痛病因较复杂,具有明显的遗传效应,而5-羟色胺(5-HT)作为参与偏头痛发病过程的重要物质,必须与其受体结合才能发挥效应,现已发现的5-HT受体亚型均包括不同的亚基,且各亚基发挥不同的作用。目前对与偏头痛相关基因的研究多仅限于亚型中影响偏头痛的片段,且研究结果存在争议。随着技术的进步,未来有望对偏头痛发病机制进行更全面系统的研究,以为偏头痛的预防和治疗提供更多思路。Migraine is a common chronic neurovascular disease that seriously affects people′s lives,and the pathogenesis is currently unclear.The etiology of migraine is complex and has significant genetic effects.As an important substance involved in the pathogenesis of migraine,5-hydroxytryptamine(5-HT)must bind to its receptor in order to exert its effects.The subtypes of discovered 5-HT receptors all include different subunits,and each subunit plays a different role.At present,research on genes related to migraine is mostly limited to the fragments in subtypes that affect migraine,and the research results are controversial.With the advancement of technology,it is expected to conduct more comprehensive and systematic research on the pathogenesis of migraine in the future,providing more ideas for the prevention and treatment of migraine.

关 键 词：偏头痛 5-羟色胺 基因 亚型 

分 类 号：R747.2[医药卫生—神经病学与精神病学]