cGAS-STING信号通路在结直肠癌治疗中的应用进展  

Progress in the Application of cGAS-STING Signaling Pathway in Treatment of Colorectal Cancer

作　　者：彭彬 梁敏[1] 姚文霞[1] 肖瑶[1] 周新科[1] PENG Bin;LIANG Min;YAO Wenxia;XIAO Yao;ZHOU Xinke(Department of Oncology,Key Laboratory of Biological Targeting Diagnosis,Therapy and Rehabilitation of Guangdong Higher Education Institutes,the Fifth Affiliated Hospital of Guangzhou Medical University,Guangzhou 510700,China)

机构地区：[1]广州医科大学附属第五医院肿瘤科,广东高校生物靶向诊治与康复重点实验室,广州510700

出　　处：《医学综述》2023年第23期5251-5256,共6页Medical Recapitulate

基　　金：广东省医学科学技术研究基金面上项目(A2021430);广东高校生物靶向诊治与康复重点实验室(2021KSYS009);广州市生物靶向诊治重点实验室(202201020379);广州市科技计划市校(院)联合资助项目(202102010128)。

摘　　要：环鸟苷酸-腺苷酸合成酶(cGAS)是一种DNA传感器,其在外源性DNA的刺激下能激活干扰素基因刺激因子(STING),诱导Ⅰ型干扰素和其他促炎性细胞因子的产生;且cGAS-STIGN信号通路的激活还能通过Ⅰ型干扰素促进瘤内CD8+T细胞募集,启动抗肿瘤免疫。目前认为STING激动剂能够作为抗肿瘤治疗的重要辅助药物,有望改善结直肠癌患者的预后,尤其是免疫治疗耐药患者。cGAS-STING信号通路可以通过启动固有免疫、肿瘤免疫以及与自噬相互作用发挥抗肿瘤效应,有望成为一个有效的潜在治疗靶点。Cyclic guanosine monophosphate adenylate synthase(cGAS)is a DNA sensor that can activate stimulator of interferon genes(STING)under the stimulation of exogenous DNA,inducing the production of typeⅠinterferon and other pro-inflammatory factors;and the activation of the cGAS-STING signaling pathway can also promote the recruitment of CD8+T cells in tumors through typeⅠinterferon,initiating anti-tumor immunity.Currently,it is believed that STING agonists can serve as important adjunctive drugs for anti-tumor therapy,with the potential to improve the prognosis of colorectal cancer patients,especially those with immunotherapy resistance.The cGAS-STING signaling pathway can exert anti-tumor effects by initiating innate immunity,tumor immunity,and interacting with autophagy,and is expected to become a potential effective therapeutic target.

关 键 词：结直肠癌 环鸟苷酸-腺苷酸合成酶-干扰素基因刺激因子信号通路 肿瘤免疫 自噬 干扰素基因刺激因子激动剂 

分 类 号：R735.3[医药卫生—肿瘤]