非酒精性脂肪性肝病诊断研究热点的可视化分析  

Visualization Analysis of Research Hotspots in Diagnosis of Nonalcoholic Fatty Liver Disease

作　　者：孙文平 温宇梅[1] 温亚辉[1] 刘佐军[1] SUN Wenping;WEN Yumei;WEN Yahui;LIU Zuojun(Department of Healthcare Medicine,Beijing Luhe Hospital,Capital Medical University,Beijing 101100,China)

机构地区：[1]首都医科大学附属北京潞河医院医疗保健病区,北京101100

出　　处：《医学综述》2023年第23期5497-5502,共6页Medical Recapitulate

摘　　要：目的基于知识可视化分析,探讨非酒精性脂肪性肝病(NAFLD)诊断领域的研究热点和发展趋势。方法收集2010年1月1日至2022年12月31日Web of Sciences数据库收录的NAFLD诊断领域英文文献,利用Microsoft Excel、VOSviewer软件进行发文量、国家、机构、作者和关键词分析。结果共收集NAFLD诊断相关研究英文文献5709篇,NAFLD诊断相关研究英文文献总发文量以及中国发文量呈上升趋势,发文量前3位的国家依次为美国、中国和意大利。发文量前3位的研究机构依次为加州大学圣地亚哥分校、上海交通大学、浙江大学。发文量≥20的研究机构中,同一国家各个机构之间合作密切,不同国家机构之间也存在合作;我国机构与国际机构之间合作较多。发文量排行前4位的作者分别为Targher G、Rohit L、Zobair MY和Christopher DB。高频关键词包括肝脂肪变性、非酒精性脂肪肝炎、肝纤维化、胰岛素抵抗、代谢综合征、肝活检、无创诊断等;研究热点主要集中在NAFLD相关代谢和心血管疾病、血清学诊断、病理和影像学诊断及其合并的其他慢性肝病的评估。结论美国在NAFLD诊断相关研究领域保持领先地位,我国相关研究发展迅速,且NAFLD的无创诊断方法是未来的研究方向。Objective To explore the research hotspots and development trends in the fields of diagnosis of nonalcoholic fatty liver disease(NAFLD)based on knowledge visualization analysis.Methods Literatures in English related to the diagnosis of NAFLD indexed in Web of Sciences databases ranging From Jan.1st,2010 to Dec.31st,2022 were collected.Microsoft Excel,VOSviewer software were used for visual analysis of number of publications,countries,institutions,authors and keywords.Results A total of 5709 English articles were collected preliminarily.The total number of English literature publications and publications from China related to the diagnosis of NAFLD is showing an increasing trend,with the top three countries in terms of publication volume being the United States,China,and Italy.The top three research institutions in terms of publication volume are the University of California,San Diego,Shanghai Jiao Tong University,and Zhejiang University.Among the research institutions with a publication volume of≥20,there is close collaboration between different institutions within the same country,as well as collaboration between institutions from different countries.Chinese institutions have a significant level of collaboration with international institutions.The top four authors in terms of publication volume are Targher G,Rohit L,Zobair MY,and Christopher DB.High-frequency keywords include hepatic steatosis,non-alcoholic fatty liver disease,liver fibrosis,insulin resistance,metabolic syndrome,liver biopsy,non-invasive diagnosis,etc.The research focuses mainly on metabolic and cardiovascular diseases related to NAFLD,serological diagnosis,pathological and imaging diagnosis,and the assessment of other chronic liver diseases associated with NAFLD.Conclusion The United States maintains a leading position in the research related to the diagnosis of NAFLD,while China has shown rapid development in this field.Non-invasive diagnostic methods for NAFLD are considered a future research direction.

关 键 词：非酒精性脂肪性肝病 诊断 可视化分析 

分 类 号：R575[医药卫生—消化系统]