胚胎植入过程中上皮间充质转化的研究进展  

Research progress on epitlielial mesenchymal transition during embryo implantation

作　　者：李冠杉 王景尚[1] 何军琴[1] LI Guanshan;WANG Jingshang;HE Junqin(Department of Traditional Chinese Medicine,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100020,China)

机构地区：[1]首都医科大学附属北京妇产医院中医科,北京100020

出　　处：《中国性科学》2023年第12期46-50,共5页Chinese Journal of Human Sexuality

基　　金：国家自然科学基金面上项目(82074477);北京市自然科学基金面上项目(7222268)。

摘　　要：上皮间充质转化(EMT)指的是具有极性的上皮细胞在形态学上转化为具有迁移侵袭能力的间充质细胞这一变化过程。研究表明在胚胎植入过程中母体子宫内膜上皮细胞(EEC)、胚胎滋养层细胞均会为胚胎的顺利植入发生EMT。因此,本文将对胚胎植入过程中EEC及滋养细胞EMT过程研究现状及其影响因素进行综述,目的是通过总结植入过程中的EMT过程,来探求由于种植失败引起的不明原因反复自然流产患者的可能发病机制和发掘潜在的临床防治手段。Epithelial mesenchymal transition(EMT)refers to the process of morphological transformation of polar epithelial cells into migratory and invasive mesenchymal cells.It has been shown that maternal endometrial epithelial cells(EEC)and embryonic trophectoderm cells undergo EMT during embryo implantation for successful embryo implantation,therefore,this paper will review the current status of research on the EMT process in endometrial epithelial cells and trophoblast cells during embryo implantation and the factors involved in the EMT process.The aim to summarize the EMT process during implantation is exploring the possible pathogenesis and potential means of clinical prevention in patients with unexplained recurrent spontaneous abortion due to implantation failure.

关 键 词：上皮间充质转化 胚胎植入 研究进展 

分 类 号：R711[医药卫生—妇产科学]