动态适形弧放射治疗晚期非小细胞肺癌的效果  

Effect of Dynamic Conformal Arc Radiation Therapy on Advanced Non-small Cell Lung Cancer

作　　者：亢崇照[1] 王晓宏[1] 王培[1] 韩振坤[1] 王文光 KANG Chongzhao;WANG Xiaohong;WANG Pei;HAN Zhenkun;WANG Wenguang(Department of Radiotherapy,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)

机构地区：[1]河南科技大学第一附属医院放疗科,河南洛阳471000

出　　处：《河南医学研究》2023年第22期4099-4103,共5页Henan Medical Research

摘　　要：目的 探讨动态适形弧放射治疗晚期非小细胞肺癌(NSCLC)的效果及对肿瘤标志物、3 a预后的影响。方法 选取2017年6月至2019年12月河南科技大学第一附属医院收治的103例晚期NSCLC患者,分为研究组(53例)和对照组(50例)。对照组接受多西他赛联合顺铂化疗,研究组在此基础上接受动态适形弧放疗。比较两组的近期疗效、肿瘤标志物、不良反应,并随访3 a评估生存预后。结果 研究组客观缓解率(50.94%)高于对照组(30.00%)(P<0.05)。研究组疾病控制率(83.02%)高于对照组(62.00%)(P<0.05)。治疗后,研究组血清糖类抗原125(CA125)、癌胚抗原(CEA)、鳞癌抗原(SCC-Ag)、细胞角蛋白19片段(CYFRA21-1)、组织多肽抗原(TPA)、细胞质胸苷激酶(TK1)水平低于对照组(P<0.05)。两组骨髓抑制、恶心呕吐、皮肤瘙痒湿疹水疱、放射性肺炎、放射性食管炎发生率比较差异无统计学意义(P>0.05)。研究组1、2、3 a生存率分别高于对照组(P<0.05)。研究组总生存期长于对照组(P<0.05)。结论 动态适形弧放射治疗晚期NSCLC可降低患者肿瘤标志物,控制肿瘤进展,提高近期效果,改善远期预后,延长生存期。Objective To investigate the effect of dynamic conformal arc therapy in treating advanced non-small cell lung cancer(NSCLC)and the influence on tumor markers and 3-year prognosis.Methods A total of 103 patients with advanced NSCLC who were admitted to the First Affiliated Hospital of Henan University of Science and Technology from June 2017 to December 2019 were divided into the study group(53 cases)and the control group(50 cases).Both groups underwent cisplatin combined with gemcitabine chemotherapy.On this basis,the study group underwent dynamic conformal arc therapy.Short-term efficacy,tumor markers and adverse reactions were compared between groups.The prognosis during 3 years of follow-up was evaluated.Results The objective response rate of the study group(50.94%)was higher than that of the control group(30.00%)(P<0.05).The disease control rate in the study group(83.02%)was higher than that in the control group(62.00%)(P<0.05).After treatment,serum carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA),squamous cell carcinoma antigen(SCC-Ag),cytokeratin 19 fragment(CYFRA21-1),tissue polypeptide antigen(TPA)and cytoplasmic thymidine kinase 1(TK1)in the study group were lower than those in the control group(P<0.05).There was no statistically difference in the incidence of bone marrow suppression,nausea and vomiting,skin itching,eczema,blisters,radiation pneumonia,and radiation esophagitis between the two groups(P>0.05).The survival rates of study groups 1,2 and 3 years were higher than those of the control group(P<0.05).The overall survival period of the study group was longer than that of the control group(P<0.05).Conclusion Dynamic conformal arc radiotherapy for advanced NSCLC can reduce tumor markers,control tumor progression,improve short-term efficacy,improve long-term prognosis,and prolong survival.

关 键 词：动态适形弧放射治疗 非小细胞肺癌 晚期肺癌 肿瘤标志物 预后 

分 类 号：R734.2[医药卫生—肿瘤]