醋酸铵促进烯胺酮的双Michael加成反应研究  

NH_(4)OAc-promoted Double Michael Addition Reactions of Enaminones

作　　者：叶青青[1] 陈浩宇 谢吉娜 何心伟[2] YE Qingqing;CHEN Haoyu;XIE Jina;HE Xinwei(School of Medicine,Chuzhou City Vocation College,Anhui Chuzhou 239000,China;Department of Chemistry and Materials Science,Anhui Normal University,Anhui Wuhu 241002,China)

机构地区：[1]滁州城市职业学院医学院,安徽滁州239000 [2]安徽师范大学化学与材料科学学院,安徽芜湖241002

出　　处：《河北师范大学学报（自然科学版）》2024年第1期53-61,共9页Journal of Hebei Normal University：Natural Science

基　　金：安徽省高校优秀青年人才支持计划项目(gxyq2022233);安徽师范大学大学生创新创业训练计划项目(202210370052,X202210370023);安徽省高等学校质量工程项目(2022jxzyk033);滁州城市职业学院课程思政示范课程(2022sfk11)。

摘　　要：在醋酸铵作用下实现取代的1,3环己二酮对取代的N,N二甲基烯胺酮的连续Michael加成反应,发展了一种合成结构新颖的3,3二环己烯基1苯基丙酮类化合物的新方法.该反应在1,2二氯乙烷中回流搅拌40min即可得到目标产物,且具有较高的收率和优异的官能团兼容性.该方法具有原料廉价易得、实验操作简单的特点,为结构多样的烷基芳基酮类化合物的合成提供了一种新颖、实用的策略.A new method for the synthesis of 3,3-dicyclohexenyl-1-phenylacetone compounds with novel structures was developed through the NH_(4) OAc-promoted sequential Michael addition reactions of substituted 1,3-cyclohexanedione with substituted N,N-dimethylenaminone.This reaction proceeded in 1,2-dichloroethane under reflux and stir for 40 min,affording the desired compounds with good yields and functional group tolerance.This method has the characteristics of cheap and easily available raw materials,and simple experimental op-erations,providing a novel and practical strategy for the synthesis of structurally diverse alkylphenone derivatives.

关 键 词：MICHAEL加成 醋酸铵 烯胺酮 环己二酮 苯基丙酮 

分 类 号：O626[理学—有机化学]