还原态铁原卟啉自由体联合人乳头瘤病毒检测在宫颈上皮病变初筛中的临床价值  

Clinical value of reduced ferroprotoporphyrin free body combined with human papilloma virus detection in preliminary screening of cervical epithelial lesions

作　　者：陈婕 曹云桂[1] 秦月勤[1] 杨波[1] 顾萍[1] 杨凤云[1] 程明军[1] CHEN Jie;CAO Yun-gui;QIN Yue-qin;YANG Bo;GU Ping;YANG Feng-yun;CHENG Ming-jun(Maternal and Child Health Care Hospital of Jiading District,Shanghai,201821,China)

机构地区：[1]上海市嘉定区妇幼保健院,上海201821

出　　处：《中国妇幼保健》2023年第24期4754-4757,共4页Maternal and Child Health Care of China

基　　金：上海市嘉定区农业和社会事业科研项目(嘉科〔2018〕16号)。

摘　　要：目的比较还原态铁原卟啉自由体(FH)检测、液基薄层细胞学检查(TCT)、人乳头瘤病毒(HPV)检测对早期宫颈癌的诊断差异,探讨FH联合HPV检测在宫颈上皮病变初筛中的临床价值。方法选取2018年5月—2021年4月在上海市嘉定区妇幼保健院行阴道镜下宫颈活检的患者474例,术前分别进行宫颈FH、TCT、HPV检测,术后根据宫颈活检病理结果分为对照组(慢性宫颈炎)120例,低度鳞状上皮内病变组(LSIL组)120例,高度鳞状上皮内病变组(HSIL组)125例及宫颈癌组109例,并分别进行比较和统计分析。结果LSIL组中,FH、TCT、HPV单独检测的阳性率分别为79.17%(95/120)、67.50%(81/120)、78.33%(94/120);FH+TCT、FH+HPV、TCT+HPV联合检测的阳性率分别为95.00%(114/120)、97.50%(117/120)、95.83%(115/120)。HSIL组中,FH、TCT、HPV单独检测的阳性率分别为80.80%(101/125)、71.20%(89/125)、88.80%(111/125);FH+TCT、FH+HPV、TCT+HPV联合检测的阳性率分别为92.80%(116/125)、98.40%(123/125)、96.00%(120/125)。宫颈癌组中,FH、TCT、HPV单独检测的阳性率分别为92.66%(101/109)、83.49%(91/109)、90.83%(99/109);FH+TCT、FH+HPV、TCT+HPV联合检测的阳性率分别为95.41%(104/109)、100.00%(109/109)、98.17%(107/109)。结论FH与HPV联合检测能够提高早期宫颈癌筛查的灵敏度,值得临床推广。Objective To compare the difference of reduced ferroprotoporphyrin free body(FH)detection,Thin-layer cytology test(TCT),and human papilloma virus(HPV)detection in diagnosis of early cervical cancer,explore the clinical value of FH detection combined with HPV detection in preliminary screening of cervical epithelial lesions.Methods A total of 474 patients who underwent cervical biopsy under colposcope in Maternal and Child Health Care Hospital of Jiading District from May 2018 to April 2021 were selected.Preoperative detection of FH,TCT,and HPV were performed respectively.According to the pathological results of cervical biopsy,the patients were divided into control group(chronic cervicitis,120 cases),low-grade squamous intraepithelial lesion(LSIL)group(120 cases),highgrade squamous intraepithelial lesion(HSIL)group(125 cases),and cervical cancer group(109 cases),the results were compared and statistically analyzed respectively.Results In LSIL group,the positive rates of FH,TCT,and HPV were 79.17%(95/120),67.50%(81/120),and 78.33%(94/120),respectively;the positive rates of FH+TCT,FH+HPV,and TCT+HPV were 95.00%(114/120),97.50%(117/120),and 95.83%(115/120),respectively.In HSIL group,the positive rates of FH,TCT,and HPV were 80.80%(101/125),71.20%(89/125),and 88.80%(111/125),respectively;the positive rates of FH+TCT,FH+HPV,and TCT+HPV were 92.80%(116/125),98.40%(123/125),and 96.00%(120/125),respectively.In cervical cancer group,the positive rates of FH,TCT,and HPV were 92.66%(101/109),83.49%(91/109),and 90.83%(99/109),respectively;the positive rates of FH+TCT,FH+HPV,and TCT+HPV were为95.41%(104/109),100.00%(109/109),and 98.17%(107/109),respectively.Conclusion FH combined with HPV detection can improve the sensitivity of early cervical cancer screening,which is worthy of clinical promotion.

关 键 词：还原态铁原卟啉自由体 液基薄层细胞学检查 人乳头瘤病毒 宫颈癌筛查 

分 类 号：R737.33[医药卫生—肿瘤]