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作 者:程明霞 伏媛[1] 张启科[1] 何锦[2] Cheng Mingxia;Fu Yuan;Zhang Qike;He Jin(Department of Hematology,Gansu Provincial Hospital,Lanzhou 730030,China;Department of Critical Care Medicine,Gansu Provincial Hospital,Lanzhou 730030,China)
机构地区:[1]甘肃省人民医院血液科,兰州730030 [2]甘肃省人民医院重症医学科,兰州730030
出 处:《肿瘤研究与临床》2023年第10期793-797,共5页Cancer Research and Clinic
基 金:甘肃省青年基金科技计划(21JR7RA427、21JR7RA648);甘肃省自然科学基金(22JR5R682、21JR11RA201)。
摘 要:细胞焦亡与免疫微环境和疾病的关系越来越受关注。细胞焦亡在抗肿瘤免疫治疗中发挥双重效应,一方面促进炎性因子的释放,形成肿瘤微环境,抑制肿瘤免疫,另一方面诱发肿瘤炎症反应,抑制肿瘤细胞的增殖。细胞焦亡、免疫微环境和肿瘤的关系在不同的组织和遗传背景是不同的。现就细胞焦亡的分子机制、肿瘤免疫微环境在血液系统恶性肿瘤中的调控作用进行综述,以期为基于细胞焦亡调控免疫微环境为靶点的抗血液系统恶性肿瘤治疗与研究提供思路。The relationship between pyroptosis and immune microenvironment and disease has received increasing attention.Pyroptosis plays a dual role in anti-tumor immunotherapy by promoting the release of inflammatory factors,forming the tumor microenvironment and suppressing tumour immunity on the one hand,and inducing the tumour inflammatory response to inhibit the proliferation of tumor cells on the other hand.The relationship between pyroptosis,immune microenvironment and tumors is different in different tissues and genetic backgrounds.This article reviews the molecular mechanisms of pyroptosis and the regulatory role of tumor immune microenvironment in hematologic malignancies,with a view to providing ideas for the anti-hematologic malignancies treatment and research based on the target of pyroptosis-regulated immune microenvironment.
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