黄芩抗白血病作用与调控骨髓微环境的相关性研究  

Correlation between anti-leukemia effect of scutellaria baicalensis Georgi and regulation of bone marrow microenvironment

作　　者：薄琳 文涛 张蕊华 李海鹰 Bo Lin;Wen Tao;Zhang Ruihua;Li Haiying(School of Public Health,Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学公共卫生学院,兰州730000

出　　处：《白血病．淋巴瘤》2023年第10期631-634,共4页Journal of Leukemia & Lymphoma

摘　　要：黄芩是临床常用的中草药之一。其化学成分众多,主要以黄酮类化合物为主,包括有黄芩素、黄芩苷、汉黄芩素等,药理作用包括抗肿瘤、抗菌、抗病毒、抗氧化等。骨髓微环境是由间充质干细胞、造血干细胞以及细胞外基质和多种可溶性因子等组成的复杂网状结构,其恶性转化影响着白血病等血液系统疾病的发生、发展。研究发现,黄芩可以作用于骨髓微环境的各组分,通过影响相关信号转导通路、细胞因子、凋亡途径和能量代谢途径等进而调控白血病的发生、发展及多药耐药。文章对黄芩及其主要化合物与白血病的相关性进行归纳,探索白血病治疗的潜在选择,以期能为寻找白血病新的作用靶点和相关调控通路提供思路。Scutellaria baicalensis Georgi,one of the commonly used Chinese herbal medicines in clinic,has a variety of chemical components,mainly flavonoids,including baicalein,baicalin,wogonin.And its pharmacological effects include anti-tumor,antibacterial,antiviral,and antioxidant.The bone marrow microenvironment is a complex network structure composed of mesenchymal stem cells,hematopoietic stem cells,extracellular matrix and various soluble factors.Its malignant transformation affects the development and progression of hematological diseases such as leukemia.Studies have found that scutellaria baicalensis Georgi can act on various components of the bone marrow microenvironment.By influencing related signal transduction pathways,cytokines,apoptosis pathways and energy metabolism pathways,the development and progression of leukemia and multidrug resistance are regulated.This review summarizes the correlation of scutellaria baicalensis and its main compounds with leukemia,explores the potential options of leukemia treatment,so as to provide ideas of seeking new targets of leukemia and related regulatory pathways.

关 键 词：黄芩 骨髓微环境 白血病 

分 类 号：R733.7[医药卫生—肿瘤]