钙结合蛋白A9在子宫颈癌中的表达及其与疗效的关系  

Expression of calcium-binding protein A9 in cervical cancer and its relationship with therapeutic effect

作　　者：陈妮 方喜平 Chen Ni;Fang Xiping(Department of Oncology,the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture,Enshi 445000,China)

机构地区：[1]恩施土家族苗族自治州中心医院肿瘤科,恩施445000

出　　处：《肿瘤研究与临床》2023年第11期827-832,共6页Cancer Research and Clinic

摘　　要：目的探讨子宫颈癌钙结合蛋白A9(S100A9)表达情况及其与患者TC(紫杉醇+卡铂)方案化疗效果的关系。方法选取2017年7月至2021年5月恩施土家族苗族自治州中心医院收治的拟行TC方案化疗的119例子宫颈癌患者开展前瞻性研究。患者均于治疗前行活组织检查取组织标本,采用免疫组织化学法检测子宫颈癌组织与癌旁正常组织中S100A9、基质金属蛋白酶9(MMP-9)、血管内皮生长因子(VEGF)表达情况,采用Spearman法分析子宫颈癌组织S100A9表达与MMP-9、VEGF表达的关系。根据化疗效果将患者分为有效组(完全缓解+部分缓解)和无效组(稳定+进展),对比两组癌组织中S100A9、MMP-9、VEGF表达情况。采用多因素logistic回归法分析TC方案化疗效果影响因素。结果与癌旁组织相比,子宫颈癌组织S100A9[90.76%(108/119)比45.38%(54/119)]、MMP-9[55.46%(66/119)比17.65%(21/119)]、VEGF[78.99%(94/119)比24.37%(29/119)]阳性表达率均升高(χ2值分别为47.03、36.69、71.09,均P<0.001);子宫颈癌组织S100A9表达与MMP-9、VEGF表达均呈正相关(r值分别为0.619、0.784,均P<0.001)。TC方案化疗有效率为47.06%(56/119)。有效组子宫颈癌组织S100A9阳性表达率较无效组高[98.21%(55/56)比84.13%(53/63),P<0.05],而MMP-9[35.71%(20/56)比73.02%(46/63)]、VEGF[67.86%(38/56)比88.89%(56/63)]阳性表达率均较无效组低(均P<0.001)。多因素logistic回归分析显示,临床分期Ⅳ期(OR=2.707,95%CI 1.865~4.119,P<0.05)、淋巴结转移(OR=4.468,95%CI 3.221~5.823,P<0.001)、深肌层浸润(OR=5.686,95%CI 4.308~7.247,P<0.001)、脉管瘤栓或子宫旁浸润(OR=3.758,95%CI 2.584~5.163,P<0.001)、癌组织MMP-9阳性表达(OR=3.904,95%CI 2.876~5.228,P<0.001)、癌组织VEGF阳性表达(OR=2.609,95%CI 1.793~4.052,P<0.05)均是TC方案化疗效果的独立危险因素,而癌组织S100A9阳性表达是TC方案化疗效果的独立保护因素(OR=0.660,95%CI 0.417~0.854,P<0.05)。结论子宫颈癌组织中S100A9表达升高,且与MMP-9、Objective To investigate the expression of calcium binding-protein A9(S100A9)in cervical cancer and its relationship with the efficacy of TC(paclitaxel+carboplatin)regimen chemotherapy in patients.Methods A total of 119 patients with cervical cancer who were scheduled to undergo TC regimen chemotherapy in the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture from July 2017 to May 2021 were selected to conduct a prospective study.The tissue samples of all patients were obtained by biopsy before treatment,and the expressions of S100A9,matrix metalloproteinase-9(MMP-9)and vascular endothelial growth factor(VEGF)in cervical cancer tissues and paracancerous normal tissues were detected by immunohistochemistry.The correlation of S100A9 expression with MMP-9 and VEGF expressions in cervical cancer tissues were analyzed by using Spearman method.The patients were divided into the effective group(complete remission+partial remission)and the ineffective group(stable disease+progressive disease)according to the effectiveness of chemotherapy,and the expressions of S100A9,MMP-9 and VEGF in cervical cancer tissues of the two groups were compared.The influencing factors for TC regimen chemotherapy efficacy were analyzed by using multivariate logistic regression method.Results Compared with paracancerous tissues,the positive expression rates of S100A9[90.76%(108/119)vs.45.38%(54/119)],MMP-9[55.46%(66/119)vs.17.65%(21/119)]and VEGF[78.99%(94/119)vs.24.37%(29/119)]were all elevated in cervical cancer tissues(χ2 values were 47.03,36.69 and 71.09,all P<0.001).The S100A9 expression in cervical cancer tissues was positively correlated with MMP-9 and VEGF expressions(r values were 0.619 and 0.784,both P<0.001).The effective rate of TC regimen chemotherapy was 47.06%(56/119).The positive expression rate of S100A9 in cervical cancer tissues of the effective group was higher than that of the ineffective group[98.21%(55/56)vs.84.13%(53/63),P<0.05],while the positive expression rates of MMP-9[35.71%(20/56)vs.73.02%(46/63)]and V

关 键 词：子宫颈肿瘤 钙结合蛋白质类 药物疗法 治疗结果 

分 类 号：R737.33[医药卫生—肿瘤]