汗孔角化症的研究进展  

Research Progress on Porokeratosis

作　　者：李静[1] 韩建文[2] LI Jing;HAN Jianwen(The first Clinical Medical College,Inner Mongolia Medical University,Hohhot 010050,China;Department of Dermatology,The Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学第一临床医学院,内蒙古呼和浩特010050 [2]内蒙古医科大学附属医院皮肤性病科,内蒙古呼和浩特010050

出　　处：《皮肤科学通报》2023年第5期641-648,共8页Dermatology Bulletin

基　　金：国家自然科学基金项目(82260619);内蒙古自治区自然科学基金(2022MS08005);内蒙古科技计划项目(2019GG082);内蒙古医科大学银屑病基础及临床研究创新团队(YKD2022TD030)。

摘　　要：汗孔角化症是一类较为少见的角化不全性皮肤疾病,其病因不明,病程呈慢性进展性,临床上该病皮损的典型表现为中央轻度萎缩、边缘呈脊状凸起的褐色环形斑疹或斑块,部分类型可表现为角化性丘疹或疣状斑块。目前越来越多证据表明胆固醇代谢过程中相关基因发生突变与汗孔角化症的发生发展有着紧密的关系,并且有相关研究证实针对胆固醇代谢的甲羟戊酸通路进行靶向治疗,对于部分类型汗孔角化症有效,为汗孔角化症的治疗提供了新思路。本文对汗孔角化症的研究进展进行简述。Porokeratosis is a relatively rare form of keratosis pilaris with an unknown etiology and a chronic progressive course.The typical clinical appearance of the lesions is a brown circular rash or plaque with a mildly atrophic middle and raised ridged edges,some types may appear as keratotic papules or warty plaques.There is growing evidence that mutations in genes involved in cholesterol metabolism are strongly associated with the development of porokeratosis.It has also been shown that targeting cholesterol metabolism in the mevalonate pathway is effective for some types of porokeratosis,providing new ideas for the treatment of porokeratosis.This article provides a brief review of the progress of research into porokeratosis.

关 键 词：汗孔角化症 甲羟戊酸 他汀类 胆固醇 

分 类 号：R751[医药卫生—皮肤病学与性病学]