血清G-17、PG Ⅰ、PG Ⅱ及PDCD5蛋白在胃癌前状态及早期胃癌诊断中的应用  

Application of serum gastrin 17,pepsinogen I,pepsinogen II,and programmed cell death protein 5 protein in the identification of gastric precancerous state and diagnosis of early gastric cancer

作　　者：高英 刘宏飞 杨君寅 朱婷婷 马永刚 Gao Ying;Liu Hongfei;Yang Junyin;Zhu Tingting;Ma Yonggang(Department of Gastroenterology,Marine Police Corps Hospital of Chinese People's Armed Police,Jiaxing 314000,Zhejiang Province,China;Department of Gastroenterology,The Second People's Hospital of Jiashan County,Jiaxing 314100,Zhejiang Province,China;Department of Gastroenterology,Jiashan Hospital of Traditional Chinese Medicine,Jiaxing 314100,Zhejiang Province,China)

机构地区：[1]武警海警总队医院消化内科,嘉兴314000 [2]嘉善县第二人民医院消化内科,嘉兴314100 [3]嘉善县中医医院消化内科,嘉兴314100

出　　处：《中国基层医药》2023年第12期1808-1813,共6页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探究血清胃泌素17(G-17)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)及程序性细胞死亡蛋白5(PDCD5)在胃癌前状态识别及在早期胃癌诊断中的应用价值。方法采用横断面研究,选取武警海警总队医院2018年7月至2022年6月收治的早期胃癌患者86例为胃癌组,选取同期该院收治的胃癌癌前状态患者80例为癌前状态组,选取同期该院健康体检人群80例为健康组,分析G-17、PGⅠ、PGⅡ及PDCD5对早期胃癌的价值效能。结果癌前状态组和胃癌组血清G-17、PGⅡ水平分别为(10.87±3.23)pmol/L、(15.78±3.33)μg/L和18.78±4.10)pmol/L、(21.25±4.48)μg/L,均高于健康组[(5.56±1.43)pmol/L、(13.52±3.02)μg/L](F=362.65、94.12,均P<0.05),PGⅠ、PDCD5水平分别为(79.52±16.62)μg/L、(1.35±0.15)μg/L和(50.06±15.58)μg/L、(0.85±0.13)μg/L,均低于健康组[(110.12±30.23)μg/L、(1.60±0.12)μg/L](F=151.07、650.56,均P<0.05);癌前状态组与胃癌组在胃癌家族史、食用高盐煎炸食物、饮酒史、幽门螺杆菌(Hp)感染等方面差异均有统计学意义(χ^(2)=10.39、4.68、11.47、36.49,均P<0.05);胃癌家族史(OR=1.42,95%CI=1.03~1.96)、Hp感染(OR=3.76,95%CI=1.30~10.85)是胃癌的危险因素(P<0.05);联合G-17、PGⅠ、PGⅡ及PDCD5四指标预测早期胃癌的效能最高(P<0.05),曲线下面积为0.982,敏感度、特异度分别为98.84%、90.00%。结论胃癌家族史、Hp感染是胃癌的危险因素,胃癌前状态及早期胃癌患者血清G-17、PGⅡ水平升高,PGⅠ、PDCD5蛋白水平降低,联合上述四项指标检测对早期胃癌有较高的诊断价值。Objective To investigate the value of serum gastrin 17(G-17),pepsinogen I(PG I),pepsinogen II(PG II),and programmed cell death protein 5(PDCD5)in the identification of gastric precancerous state and the diagnosis of early gastric cancer.Methods A total of 86 patients with early gastric cancer who received treatment at the Marine Police Corps Hospital of Chinese People's Armed Police Force from July 2018 to June 2022 were included in the gastric cancer group.Eighty patients with gastric precancerous states who concurrently received treatment in the same hospital were included in the precancerous state group.An additional 80 partiapants who concurrently received physical examination in the same hospital were included in the healthy group.The value of G-17,PG I,PG II,and PDCD5 in the diagnosis of early gastric cancer was analyzed.Results The levels of G-17 and PG II in the precancerous state group[(10.87±3.23)pmol/L,(15.78±3.33)μg/L]and gastric cancer group[(18.78±4.10)pmol/L,(21.25±4.48)μg/L]were significantly higher compared with the healthy group[(5.56±1.43)pmol/L,(13.52±3.02)μg/L,F=362.65,94.12,all P<0.05].The levels of PG I and PDCD5 in the precancerous state group[(79.52±16.62)μg/L,(1.35±0.15)μg/L]and gastric cancer group[(50.06±15.58)μg/L,(0.85±0.13)μg/L]were significantly lower than those in the healthy group[(110.12±30.23)μg/L,(1.60±0.12)μg/L,F=151.07,650.56,all P<0.05)].There were significant differences between the precancerous state and the gastric cancer groups in terms of family history of gastric cancer,consumption of high salt fried foods,alcohol consumption history,and Helicobacter pylori(Hp)infection(χ^(2)=10.39,4.68,11.47,36.49,all P<0.05).Family history of gastric cancer(OR=1.42,95%CI=1.03-1.96)and Hp infection(OR=3.76,95%CI=1.30-10.85)were identified as risk factors for gastric cancer(P<0.05).The combination of G-17,PG I,PG II,and PDCD5 had the highest predictive efficiency for early gastric cancer(P<0.05),with the area under the receiver operating characteristic curve bein

关 键 词：胃肿瘤 癌前状态 胃泌素类 胃蛋白酶原类 诊断 因素分析 统计学 敏感性与特异性 程序性细胞死亡蛋白5 

分 类 号：R735.2[医药卫生—肿瘤]