乳腺癌化疗患者的焦虑抑郁及其与化疗毒副反应的相关性  

Anxiety and depression of breast cancer patients undergoing chemotherapy and their correlation with chemotherapy side effects

作　　者：陈超 杨世威 冯丽[1] 郭飞跃 秦政 张静[1] CHEN Chao;YANG Shiwei;FENG Li;GUO Feiyue;QIN Zheng;ZHANG Jing(Department of Glandular Surgery,Hebei General Hospital,Hebei Shijiazhuang 050051,China;Graduate School of Hebei Medical University,Hebei Shijiazhuang 050017,China)

机构地区：[1]河北省人民医院腺体外科,河北石家庄050051 [2]河北医科大学研究生学院,河北石家庄050017

出　　处：《现代肿瘤医学》2024年第2期270-276,共7页Journal of Modern Oncology

摘　　要：目的:观察乳腺癌化疗患者抑郁和焦虑的发病率及其影响因素,并研究焦虑抑郁和化疗毒副反应的相关性。方法:本研究回顾性收集了2020年2月至2023年2月在我院腺体外科住院手术并化疗的乳腺癌患者为研究对象,采用自行设计的一般资料调查表、抗癌药物常见毒副反应分级标准(WHO)、不良事件通用术语标准(CTCAE)5.0版、医院焦虑抑郁量表(HADS)进行问卷调查。分析影响乳腺癌术后化疗患者抑郁和焦虑的独立危险因素,以及焦虑抑郁和化疗毒副反应的相关性。结果:141例乳腺癌患者中焦虑症患者为72例(51.06%);抑郁症患者为61例(43.26%)。文化程度高、经济负担重、手术方式为乳房切除术是乳腺癌合并焦虑或抑郁的独立危险因素。焦虑评分与腹泻、口腔黏膜炎、疼痛、手足综合征、间接胆红素升高呈正相关(P<0.05);抑郁评分与腹泻、手足综合征、间接胆红素升高、尿素升高呈正相关(P<0.05)。结论:乳腺癌化疗患者抑郁、焦虑的发病率较高,并受患者的文化程度、经济水平及手术方式的影响。焦虑、抑郁评分与化疗毒副反应存在一定联系。在临床工作中,医护人员可通过患者的一般特征对患焦虑或抑郁的高危人群重点关注,采取有效的心理干预,降低患者焦虑、抑郁等负性情绪的发生,提高患者生活质量,改善其预后。Objective:To investigate the incidence of depression and anxiety in breast cancer chemotherapy patients and their influencing factors,and to study the association between anxiety and depression and chemotherapy side effects.Methods:This study retrospectively collected breast cancer patients who were hospitalized for surgery and chemotherapy in department of glandular surgery of our hospital from February 2020 to February 2023 as the study subjects,and used self-designed general data questionnaires,anticancer drug toxicity and adverse reactions criteria(WHO),adverse event general terminology standard(CTCAE)version 5.0,and hospital anxiety and depression scale(HADS)to conduct questionnaires.The independent risk factors affecting depression and anxiety in postoperative chemotherapy patients with breast cancer surgery,as well as the association between anxiety and depression and chemotherapy side effects were analyzed.Results:Among the 141 breast cancer patients,there were 72 patients(51.06%)with anxiety and 61 patients(43.26%)with depression.High literacy,heavier financial burden and total mastectomy were independent risk factors for breast cancer with anxiety or depression.Anxiety scores were positively correlated with diarrhea,oral mucositis,pain,hand-foot syndrome and elevated indirect bilirubin(P<0.05).Depression scores were positively correlated with diarrhea,hand-foot syndrome,elevated indirect bilirubin and elevated urea(P<0.05).Conclusion:Chemotherapy patients for breast cancer have a high incidence of depression and anxiety,and are affected by the patient's education level,economic level and surgical modalities.Anxiety and depression scores are associated with chemotherapy side effects.In clinical work,medical staff can focus on high-risk groups suffering from anxiety or depression through the general characteristics of patients,and take effective psychological interventions to reduce the occurrence of negative emotions such as anxiety and depression,improve the quality of life of patients,and improve their

关 键 词：乳腺癌 焦虑 抑郁 影响因素 化疗毒副反应 

分 类 号：R737.9[医药卫生—肿瘤]