非霍奇金淋巴瘤患者自体外周血造血干细胞动员采集的影响因素分析  

Influencing factors of autologous peripheral blood hematopoietic stem cell mobilization and collection in patients with non-Hodgkin's lymphoma

作　　者：梁霄[1] 仙木斯亚·买买提热夏提 郑晓燕[2] 王晓宁[2] 闻淑娟[1] LIANG Xiao;Xianmusiya·Maimaitirexiati;ZHENG Xiaoyan;WANG Xiaoning;WEN Shujuan(Department of Lymphoma,the Affiliated Tumor Hospital of Xinjiang Medical University,Xinjiang Urumqi 830011,China;Department of Hematology,the First Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Xi'an 710061,China)

机构地区：[1]新疆医科大学附属肿瘤医院淋巴瘤内科,新疆乌鲁木齐830011 [2]西安交通大学第一附属医院血液科,陕西西安710061

出　　处：《现代肿瘤医学》2024年第2期304-308,共5页Journal of Modern Oncology

基　　金：新疆维吾尔自治区自然科学基金项目(编号:2021D01C416);自治区科技支疆项目计划(指令性)项目(编号:2022E02053)。

摘　　要：目的:分析非霍奇金淋巴瘤患者自体外周血造血干细胞动员采集的影响因素。方法:收集西安交通大学第一附属医院血液内科2011年1月至2020年6月共计85例行自体外周血造血干细胞动员采集的非霍奇金淋巴瘤患者临床资料。采用单因素和多因素分析性别、年龄、疾病分型、Ann Arbor分期、移植前状态、国际预后指数评分、动员前化疗次数及动员方案对造血干细胞采集效果的影响。结果:单因素分析发现患者年龄、疾病分型、分期、动员前状态与动员采集CD34^(+)细胞数、动员采集成功率无相关性(P>0.05);男性患者CD34^(+)细胞数多于女性(P=0.01);动员前化疗周期≤4次是采集的有利因素(P<0.05);CHOP-E及CHOP-MTX联合G-CSF动员方案均可作为自体外周血造血干细胞有效的动员方案。多因素结果显示采集前化疗周期数是影响造血干细胞采集成功的独立因素,动员前化疗周期>4次是造血干细胞能否采集成功的不良因素。结论:CHOP-MTX+G-CSF动员方案比较CHOP-E+G-CSF采集CD34^(+)细胞数更多。男性患者、动员采集前化疗周期数较少时更有利于NHL患者自体外周血造血干细胞动员采集。Objective:To determine the factors affecting the mobilization and collection of autologous peripheral blood hematopoietic stem cells(APBSC)in patients with non-Hodgkin's lymphoma(NHL).Methods:The clinical data of 85 NHL patients who received the mobilization and collection of APBSC in the Department of Hematology of the First Affiliated Hospital of Xi'an Jiaotong University from January 2011 to June 2020 were collected.The effects of gender,age,disease type,Ann Arbor stage,pre-transplant disease status,International Prognostic Index(IPI)score,chemotherapy cycle,and different schemes on APBSC collection were analyzed by univariate and multivariate Logisitic regression.Results:Univariate analysis showed that there was no correlation between the age,disease type,Ann Arbor stage,disease status and the number of CD34^(+)cells collected or the collection success rate(P>0.05).Male patients had more CD34^(+)cells than female patients(P=0.01).Chemotherapy cycles≤4 times before mobilization were favorable factors for collection(P<0.05).CHOP-E and CHOP-MTX combined with G-CSF mobilization schemes could be used as effective mobilization schemes for APBSC.Multivariate results showed that the number of chemotherapy cycles before collection was an independent factor affecting the success of hematopoietic stem cell collection,and the number of chemotherapy cycles>4 times before mobilization was a negative factor for the success of hematopoietic stem cell collection.Conclusion:Compared with CHOP-E+G-CSF,CHOP-MTX+G-CSF mobilized more CD34^(+)cells.Male patients and those with fewer chemotherapy cycles before mobilization collection are more conducive to the mobilization and collection of autologous peripheral blood hematopoietic stem cells in NHL patients.

关 键 词：非霍奇金淋巴瘤 自体造血干细胞移植 干细胞动员采集 

分 类 号：R733[医药卫生—肿瘤]