基于多参数磁共振和PSMA PET/CT的前列腺靶向穿刺研究进展  

Research progress in targeted prostate biopsy based on mpMRI and PSMA PET/CT

作　　者：陈舰 武鹏 胡伟 张景良 焦健华 马帅军 杨文辉 崔超超 秦卫军 CHEN Jian;WU Peng;HU Wei;ZHANG Jingliang;JIAO Jianhua;MA Shuaijun;YANG Wenhui;CUI Chaochao;QIN Weijun(Xi'an Medical University,Shaanxi Xi'an 710021,China;Department of Urology,First Affiliated Hospital of Air Force Military Medical University,Shaanxi Xi'an 710032,China)

机构地区：[1]西安医学院,陕西西安710021 [2]空军军医大学第一附属医院泌尿外科,陕西西安710032

出　　处：《现代肿瘤医学》2024年第2期387-391,共5页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:81172146)。

摘　　要：在西方发达国家,前列腺癌(prostate cancer,PCa)发病率和死亡率趋于高水平。而在我国,虽然发病率仍处于较低水平,但随着人群寿命的提高、饮食习惯的改变和社会经济的发展,近年来PCa发病率明显升高。早发现、早诊断、早治疗对PCa的诊疗尤为重要,传统的筛查诊断方法包括血清前列腺特异性抗原(prostate specific antigen,PSA)检测、直肠指诊(digital rectal examination,DRE)和前列腺穿刺活检,其中活检病理一直是PCa诊断的金标准。目前,临床主要通过超声引导穿刺活检,但超声引导存在诊断率低及前列腺特殊部位难以引导等缺点,因此,为提高检出效率及准确性,近年多参数磁共振(multi-parameter magnetic resonance imaging,mpMRI)或前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)正电子发射计算机断层显像(positron emission tomography computed tomography,PET/CT)与超声结合靶向穿刺显示出了良好的临床应用潜力。本文旨在综述这两种靶向穿刺方法的研究进展,为其能更好提高早诊率,进一步服务临床诊断奠定基础。The incidence and mortality of prostate cancer(PCa)are increasing in western developed countries.With the increase of aging population,the improvement of dietary life and the development of social economy,prostate cancer is significantly increasing in China.Early detection,diagnosis and treatment is particularly important for treatment selection.Traditional diagnostic methods,including serum prostate specific antigen(PSA),digital rectal examination(DRE)and prostate biopsy,in which biopsy pathology has always been the gold standard for the diagnosis of prostate cancer.At present,ultrasound-guided biopsy is mainly used in clinic,but there are some shortcomings such as low diagnosis rate and difficult to guide special parts of the prostate.Therefore,to improve the detection efficiency and accuracy,the combination of multi-parameter nuclear magnetic resonance(mpMRI)or PSMA PET/CT with rectal ultrasound targeted biopsy has shown good potential in clinical application.The purpose of this paper is to review the research progress of these two targeted biopsy methods,so as to lay a foundation for improving the rate of early diagnosis and further serving clinical diagnosis.

关 键 词：前列腺癌 多参数磁共振 前列腺特异性膜抗原 正电子发射计算机断层显像 前列腺穿刺 

分 类 号：R737.25[医药卫生—肿瘤]