下呼吸道及肺癌内菌群与肺癌发生发展的关系及其临床应用  

Relationship between Bacteria in the Lower Respiratory Tract/Lung Cancer and the Development of Lung Cancer as well as Its Clinical Application

作　　者：李博文 黄志诚 王亚东 薛剑超 夏研凯 徐源[1] 杨华夏[2] 梁乃新[1] 李单青 Bowen LI;Zhicheng HUANG;Yadong WANG;Jianchao XUE;Yankai XIA;Yuan XU;Huaxia YANG;Naixin LIANG;Shanqing LI(Department of Thoracic Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences(CAMS)and Peking Union Medical College(PUMC),Beijing 100730,China;Department of Rheumatology and Clinical Immunology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences(CAMS)and Peking Union Medical College(PUMC),Beijing 100730,China)

机构地区：[1]中国医学科学院,北京协和医学院,北京协和医院胸外科,北京100730 [2]中国医学科学院,北京协和医学院,北京协和医院风湿免疫科,北京100730

出　　处：《中国肺癌杂志》2023年第12期950-956,共7页Chinese Journal of Lung Cancer

基　　金：中央高水平医院临床科研业务费(No.2022-PUMCH-B-011、No.2022-PUMCH-A-106);希思科-默沙东肿瘤研究基金项目(No.CSCO-YMSDPU2021-0190、No.CSCO-Y-MSD2020-0270);希思科-领航肿瘤研究基金项目(No.Y-2019AZMS-0452)资助。

摘　　要：由于16S rRNA测序技术的发展,长期以来被认为是不存在的下呼吸道菌群也逐步被揭示出来。这些微生物与疾病(如肿瘤)的相关性是近年来的研究热点。由于肿瘤周围环境中的菌群会进入肿瘤内部,研究者们也开始关注肿瘤内菌群的生物学行为以及其与肿瘤的相互作用。在这篇综述中,我们展示了下呼吸道菌群的特点,并总结了近年来关于这些菌群与肺癌关系的相关研究成果。同时,我们也对肿瘤内菌群的基本特征进行整理,并着重阐述肺癌内菌群的特点及其与肺癌发生、发展的关系。最后,我们综述了下呼吸道和肺癌内菌群在临床上的转化应用方向,并汇总了样本采集、测序和控制污染的要点,希望为肿瘤的早筛和治疗提供新的思路。Due to the advancement of 16S rRNA sequencing technology,the lower respiratory tract microbiota,which was considered non-existent,has been revealed.The correlation between these microorganisms and diseases such as tumor has been a hot topic in recent years.As the bacteria in the surrounding can infiltrate the tumors,researchers have also begun to pay attention to the biological behavior of tumor bacteria and their interaction with tumors.In this review,we present the characteristic of the lower respiratory tract bacteria and summarize recent research findings on the relationship between these microbiota and lung cancer.On top of that,we also summarize the basic feature of bacteria in tumors and focus on the characteristic of the bacteria in lung cancer.The relationship between bacteria in lung cancer and tumor development is also been discussed.Finally,we review the potential clinical applications of bacterial communities in the lower respiratory tract and lung cancer,and summarize key points of sample collection,sequencing,and contamination control,hoping to provide new ideas for the screening and treatment of tumors.

关 键 词：肺肿瘤 呼吸系统 细菌 

分 类 号：R734.2[医药卫生—肿瘤]