立体定向放疗后原发病灶旁新发快速进展磨玻璃型肺腺癌1例  

A Case of New Rapidly Progressing Ground-glass Nodule Lung Adenocarcinoma Near Primary Lesion after Stereotactic Body Radiation Therapy

作　　者：王思聪 李林峰 程远大[1] Sicong WANG;Linfeng LI;Yuanda CHENG(Department of Thoracic Surgery,Xiangya Hospital,Central South University,Changsha 410008,China)

机构地区：[1]中南大学湘雅医院胸外科,长沙410008

出　　处：《中国肺癌杂志》2023年第12期957-960,共4页Chinese Journal of Lung Cancer

摘　　要：磨玻璃型肺癌临床常表现为惰性,其接受立体定向放疗(stereotactic body radiation therapy,SBRT)治疗后长期随访的临床研究较少。本文提供1例接受SBRT治疗的磨玻璃型肺癌的成功案例,但随访中发现临近SBRT治疗靶区的肺组织内,新发1例磨玻璃结节。该结节进展迅速,经手术切除证实为肺腺癌,但分子病理结果及基因检测未见明显高危因素和相关驱动基因。新发磨玻璃结节是否与既往SBRT治疗有关,值得进一步研究。本案例提示,SBRT治疗后的随访复查,应警惕靶区及临近肺组织内新发快速进展型肺癌的发生。Ground-glass nodule(GGN)lung cancer often progresses slowly in clinical and there are few clinical studies on long-term follow-up of patients with operable GGN lung cancer treated with stereotactic body radiation therapy(SBRT).We present a successful case of GGN lung cancer treated with SBRT,but a new GGN was found in the lung adjacent to the SBRT target during follow-up.The nodule progressed rapidly and was confirmed as lung adenocarcinoma by surgical resection.No significant risk factors and related driving genes were found in molecular pathological findings and genetic tests.It deserves further study whether new GGN is related to the SBRT.This case suggests that the follow-up after SBRT should be vigilant against the occurrence of new rapidly progressive lung cancer in the target area and adjacent lung tissue.

关 键 词：肺肿瘤 立体定向放疗 磨玻璃结节 进展 

分 类 号：R734.2[医药卫生—肿瘤]