荧光膀胱镜下尿道膀胱肿瘤电切术与膀胱部分切除术对老年浅表性膀胱癌患者疗效和预后的影响  

Effect of Fluoroscopic Cystoscopic Electrodesiccation of Urethral Bladder Tumors and Partial Cystectomy on the Outcome and Prognosis of Elderly Patients with Superficial Bladder Cancer

作　　者：柳松 Liu Song(Surgery Department,Tianjin Huanghe Hospital,Tianjin,300000,China)

机构地区：[1]天津市黄河医院外科,天津300000

出　　处：《黑龙江医学》2023年第24期2972-2974,共3页Heilongjiang Medical Journal

摘　　要：目的:研究荧光膀胱镜下尿道膀胱肿瘤电切术(TURBT)与膀胱部分切除术对老年浅表性膀胱癌(SBC)患者疗效和预后的影响及血浆内前列腺素E2(PGE2)、P物质的差异性表达。方法:选取2019年1月—2020年12月天津市黄河医院收治的120例SBC患者作为研究对象,采用随机数表法分为观察组和对照组,每组各60例。观察组患者采取TURBT手术治疗,对照组常规进行膀胱部分切除术治疗。比较两组患者复发率、生存期、免疫指标、PGE2、P物质水平以及并发症之间的差异。结果:观察组患者1年内浅表性膀胱癌的复发率显著低于对照,差异有统计学意义(χ^(2)=3.931,P<0.05);通过一年的随访,观察组患者的总生存期及无进展生存期显著低于对照组,差异有统计学意义(t=2.837、3.295,P<0.05);治疗后,观察组患者的CD3^(+)、CD4^(+)、CD8、CD4^(+)/CD8^(+)显著高于对照组,差异有统计学意义(t=4.501、6.316、6.648、6.012,P<0.05);治疗后,观察组患者的PGE2低于对照组,P物质水平高于对照组,差异有统计学意义(t=10.801、5.594,P<0.05);两组患者治疗期间并发症差异无统计学意义(χ^(2)=0.341、1.031,P>0.05)。结论:荧光膀胱镜下TURBT术对老年SBC患者进行治疗,血浆内PGE2、P物质显著改善,治疗效果以及预后生存期显著改善。Objective:To investigate the effect of fluoroscopic cystoscopic electrical resection of urethral bladder tumors(TURBT)versus partial cystectomy on the outcome and prognosis of elderly patients with superficial bladder cancer(SBC)and the differential expression of prostaglandin E2(PGE2)and substance P in plasma.Methods:120 patients with superficial bladder cancer admitted to the hospital from January 2019 to December 2020 were selected as the study subjects,and were divided into observation group and control group using the random number table method,with 60 cases in each group.The observation group was treated with TURBT surgery and the control group underwent conventional partial cystectomy.The differences between the two groups in terms of recurrence rate,survival,immune indexes,PGE2 and substance P levels,and complications were compared.Results:The recurrence rate of superficial bladder cancer within 1 year was significantly lower in the observation group than in the control,and the difference was statistically significant(χ^(2)=3.931,P<0.05).Through one-year follow-up,the overall survival and progression-free survival of the observation group were significantly lower than those of the control group,with statistically significant differences(t=2.837,3.295,P<0.05).After treatment,patients in the observation group had significantly higher CD3^(+),CD4^(+),CD8,and CD4^(+)/CD8^(+)than those in the control group,with statistically significant differences(t=4.501,6.316,6.648,6.012,P<0.05).After treatment,the patients in the observation group had lower PGE2 and higher substance P levels than the control group,with statistically significant differences(t=10.801,5.594,P<0.05).The difference in the incidence of complications during treatment between the two groups was not statistically significant(χ^(2)=0.341,1.031,P>0.05).Conclusion:Fluoroscopic cystoscopic TURBT in elderly patients with superficial bladder cancer showed significant improvement in intraplasma PGE2 and substance P.Treatment outcomes as well as prognost

关 键 词：荧光膀胱镜 尿道膀胱肿瘤电切术 浅表性膀胱癌 前列腺素E2 P物质 

分 类 号：R737.14[医药卫生—肿瘤]