FOSL1在消化系恶性肿瘤中的研究进展  

Progress of FOSL1 in malignant tumors of the digestive system

作　　者：王继伟 郑强[1] 丁秋莲 邓桥 WANG Jiwei;ZHENG Qiang;DING Qiulian;DENG Qiao(Department of Gastroenterology,First Affiliated Hospital of Jiamusi University,Jiamusi,Heilongjiang 154002,China)

机构地区：[1]佳木斯大学附属第一医院消化内科,黑龙江佳木斯154002

出　　处：《医药前沿》2023年第34期31-33,36,共4页Journal of Frontiers of Medicine

摘　　要：随着消化系恶性肿瘤的全球发病率不断上升,研究其发病机制成为当前重要的课题。作为Ras和ERK的主要效应物,致癌转录因子FOS样抗原1(FOSL1)被证明与更具攻击性的表型和癌症进展有关。在多种人类癌中检测到FOSL1的过度表达,包括结肠癌、卵巢癌、乳腺癌、肝癌、肺癌和食道鳞状细胞癌等。本文就FOSL1基因在消化系统恶性肿瘤中的研究进展进行了综述。With the global incidence rate of malignant tumors of the digestive system rising,the study of its pathogenesis has become an important topic at present.As the main effector of Ras and ERK,the oncogenic transcription factor FOS like antigen 1(FOSL1)has been shown to be associated with more aggressive phenotypes and cancer progression.FOSL1 overexpression was detected in a variety of human cancers,including colon cancer,ovarian cancer,breast cancer,liver cancer,lung cancer and esophageal squamous cell carcinoma.This article reviews the research progress of FOSL1 gene in malignant tumors of the digestive system.

关 键 词：综述 FOSL1 恶性肿瘤 

分 类 号：R730[医药卫生—肿瘤]