米诺环素软膏对慢性牙周炎局部炎症反应的辅助疗效观察  

Observation of auxiliary efficacy of minocycline ointment on local inflammatory response in chronic periodontitis

作　　者：叶阳阳 YE Yangyang(Wenzhou Central Hospital,Wenzhou 325000,Zhejiang,China)

机构地区：[1]温州市中心医院,浙江温州3250001

出　　处：《中国现代医生》2023年第35期72-75,共4页China Modern Doctor

摘　　要：目的探讨米诺环素软膏在慢性牙周炎中的疗效及对局部炎症反应的辅助效果。方法选取笔者医院2022年2月至9月临床收治的88例慢性牙周炎患者为研究对象,随机将其分为对照组(给予常规治疗)和研究组(给予米诺环素软膏治疗),每组44例。对两组患者的临床治疗效果、龈沟液中炎症因子、牙周改善情况和胶原指标进行观察和比较。结果治疗2周时,研究组和对照组临床总有效率分别为81.82%和63.64%,研究组略高于对照组,但差异无统计学意义(P>0.05);治疗4周时,研究组的总有效率(95.45%)高于对照组(77.27%),且差异有统计学意义(P<0.05);治疗2周和治疗4周时,研究组的高敏C反应蛋白和白细胞介素-10炎症因子指标水平均优于对照组,且差异有统计学意义(P<0.05);治疗2周和治疗4周时,研究组的菌斑指数、牙龈指数和牙周袋深度等指标水平均优于对照组,且差异有统计学意义(P<0.05);治疗1个疗程和治疗2个疗程时,研究组的龈沟液胶原指标优于对照组,且差异有统计学意义(P<0.05)。结论采用米诺环素软膏治疗慢性牙周炎,能够改善患者局部牙周组织的炎症反应过程和微生态平衡状态,对于促进牙周组织恢复具有重要的临床意义,是临床治疗慢性牙周炎的理想方式之一。Objective To investigate the effect of minocycline ointment in chronic periodontitis and its auxiliary efficacy on local inflammatory response.Methods From February to September 2022,88 patients with chronic periodontitis treated were randomly divided into control group(routine treatment)and study group(treated with minocycline ointment),44 cases in each group.The clinical therapeutic effects,inflammatory factors in gingival crevicular fluid,periodontal improvement and collagen indexes of the two groups were compared.Results At 2 weeks of treatment,the total clinical effective rates of the two groups were 81.82%and 63.64%respectively.The study group was slightly higher than the control group,but the difference was not statistically significant(P>0.05).At 4 weeks of treatment,the total effective rate in the study group(95.45%)was higher than that in the control group(77.27%),the difference was statistically significant(P<0.05).At 2 and 4 weeks of treatment,the levels of hypersensitive-C-reactive protein and interleukin-10 inflammatory factors in the study group were better than those in the control group,and the differences were statistically significant(P<0.05).At 2 and 4 weeks of treatment,the levels of plaque index,gingival index and periodontal pocket depth in the study group were better than those in the control group,and the differences were statistically significant(P<0.05).after one course of treatment and two courses of treatment,the collagen index of gingival crevicular fluid in the study group was better than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Minocycline ointment can improve the inflammatory reaction process and microecological balance of local periodontal tissue in patients with chronic periodontitis.It has important clinical significance for promoting the recovery of periodontal tissue and is one of the ideal ways for clinical treatment of chronic periodontitis.

关 键 词：米诺环素软膏 慢性牙周炎 炎症反应 临床疗效 

分 类 号：R781.42[医药卫生—口腔医学]