前瞻性队列研究-甘油三酯葡萄糖指数与急性胰腺炎发病风险  

Correlation between triglyceride glucose index and risk of acute pancreatitis:A prospective cohort study

作　　者：张冰[1] 孙秋[1] 杜丽明[2] 陈朔华 ZHANG Bing;SUN Qiu;DU Liming;CHEN Shuohua(Department of Hepatobiliary Diseases,Kailuan General Hospital,Tangshan 063000,China;不详)

机构地区：[1]开滦总医院中西医肝胆科,河北唐山063000 [2]开滦总医院中医科,河北唐山063000 [3]开滦员工健康保障中心,河北唐山063000

出　　处：《实用医学杂志》2023年第23期3116-3119,共4页The Journal of Practical Medicine

基　　金：河北省卫健委科研立项(编号:20221167)。

摘　　要：目的探讨开滦集团职工不同甘油三酯葡萄糖指数(riglyceride glucose index,TyG)水平对急性胰腺炎(acute pancreatitis,AP)发生事件的影响。方法以首次参加2006-2009年健康体检的开滦研究人群作为观察队列,去除临床资料不完整者,采用前瞻性队列研究方法,纳入研究对象共124516例,以Log-Rank法进行检验,计算该研究对象中新发AP的累积发病率和发病密度,先用单因素Cox回归模型筛选出有统计学差异的自变量,将自变量代入多因素Cox回归模型,分析不同TyG分组水平对新发AP事件的影响。结果研究人群按四分位法将TyG指数分为4组(TyG≤6.59,6.59<TyG≤6.98,6.98<TyG≤7.46,TyG>7.46),随访(12.59±0.98)年,共发生AP 399例,4组发病密度呈递增趋势,经Log-Rank检验,差异有统计学意义(P<0.01)。Cox比例风险回归模型校正多种混杂因素后,结果显示:TyG>7.46组新发AP风险明显增加,HR=1.94[(95%CI(1.42,2.65),P<0.01]。结论基线TyG指数水平在7.46以上增加了新发AP的发病风险,提示在一定程度上胰岛素抵抗(insulin resistance,IR)和AP的发生密切相关。Objective To investigate the correlations of triglyceride glucose index(TyG)levels at different baselines with the risk of new-onset acute pancreatitis(AP)among the workers at Kailuan Group.Methods A total of 124516 subjects were enrolled from 2006 to 2009 and followed up by health examinations of the workers in the group.The subjects with a history of AP or incomplete information on TG and FPG data were excluded.The cumulative incidence rate was determined by Log-Rank method.Multivariate Cox proportional hazards regression model was used to calculate hazard ratios(HR)for AP related to baseline TyG level after adjusting for the effects of multiple confunding factors.Results The subjects were divided into four groups(TyG≤6.59,6.59<TyG≤6.98,6.98<TyG4≤7.46,TyG>7.46)according to the TyG levels,and the incidence of new-onset AP was observed in all the groups.For a follow-up of(12.59±0.98)years,399 cases of AP were observed.The corresponding incidence of AP in each tertile was 1.67,2.32,2.53,and 3.65 events per 10,000 person-years,respectively.After Cox analysis and correction of multiple confounding factors,the risk of AP incidence was increased in the TyG>7.46 group,with an HR of 1.94[(95%CI(1.42,2.65),P<0.01].Conclusion TyG at its baseline of above 7.46 can increase the risk of AP.

关 键 词：甘油三酯葡萄糖指数 急性胰腺炎 代谢综合征 胰岛素抵抗 

分 类 号：R576[医药卫生—消化系统]