《动物研究:体内实验报告》即ARRIVE 2.0指南的解释和阐述(四)  

Explanation and Elaboration for the ARRIVE Guidelines 2.0-Reporting Animal Research and In Vivo Experiments(Ⅳ)

作　　者：李夏莹 田永路[3] 刘晓宇 卢选成[5] 陈国元 卢晓 白玉 高静 李垚 陶雨风[11] 庞万勇 韦玉生 LI Xiaying;TIAN Yonglu;LIU Xiaoyu;LU Xuancheng;CHEN Guoyuan;LU Xiao;BAI Yu;GAO Jing;LI Yao;TAO Yufeng;PANG Wanyong;WEI Yusheng(Laboratory Animal Research Center,Peking University,Beijing 100871,China;School of Life Science,Peking University,Beijing 100871,China;School of Psychological and Cognitive Sciences,Peking University,Beijing 100871,China;National Institute for Occupational Health and Poison Control,Chinese Center for Disease Control and Prevention,Beijing 100050,China;Laboratory Animal Centre,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Animal Core Facility,Center for Excellence in Molecular Cell Science,Chinese Academy of Science,Shanghai 200031,China;Dizal Pharmaceuticals Co.,Ltd.,Shanghai 201203,China;Novo Nordisk Research Centre China,Beijing 102206,China;Clinical Research Institute,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Department of Laboratory Animal Science,School of Medicine,Shanghai Jiao Tong University,Shanghai 200025,China;China National Accreditation Service for Conformity Assessment,Beijing 100062,China;Translational in Vivo Model Research Platform,Sanofi G&D,Beijing 100022,China)

机构地区：[1]北京大学实验动物中心,北京100871 [2]北京大学生命科学学院,北京100871 [3]北京大学心理与认知科学学院,北京100871 [4]中国疾病预防控制中心职业卫生与中毒控制所,北京100050 [5]中国疾病预防控制中心实验动物中心,北京102206 [6]中国科学院分子细胞科学卓越创新中心动物实验技术平台,上海200031 [7]迪哲医药股份有限公司,上海201203 [8]北京诺和诺德医药科技有限公司,北京102206 [9]上海交通大学医学院临床研究中心,上海200025 [10]上海交通大学医学院实验动物科学部,上海200025 [11]中国合格评定国家认可中心,北京100062 [12]赛诺菲公司全球研发中心转化体内模型研究平台,北京100022

出　　处：《实验动物与比较医学》2023年第6期659-668,共10页Laboratory Animal and Comparative Medicine

基　　金：国家重点研发计划“实验动物共性关键质量评价技术标准研究”(2022YFF0711000);中国科学技术期刊编辑学会2023年翰笔计划医学中青年编辑科研项目“动物实验医学研究及报告规范化的国际对标(指南汉化推广)”(HBJH-2023-A16)。

摘　　要：提高生物医学研究结果的可重复性是一项重大挑战,研究人员透明且准确地报告其研究过程有利于读者对该研究结果的可靠性进行评估,进而重复该实验或在该成果的基础上进一步探索。ARRIVE 2.0指南是英国国家3Rs中心(NC3Rs)于2019年组织发布的一份适用于任何与活体动物研究报告相关的指导性清单,用以提高动物体内实验设计、实验实施和实验报告的规范性,以及动物实验结果的可靠性、可重复性和临床转化率。ARRIVE 2.0指南的使用不仅可以丰富动物实验研究报告的细节,确保动物实验结果信息被充分评估和利用,还可以使读者准确且清晰地了解作者所表述的内容,促进基础研究评审过程的透明化和完整性。本文是在国际期刊遵循ARRIVE 2.0指南的最佳实践基础上,对2020年发表于PLoS Biology期刊上的ARRIVE 2.0指南完整解读版(https://arriveguidelines.org)第四部分包括“推荐11条”里的第1~5条:“摘要”、“研究背景”、“研究目标”、“伦理声明”和“饲养场所和饲养”等内容进行了编译、解释和阐述,以期促进国内研究人员充分理解并使用ARRIVE 2.0指南,提高实验动物研究及报告的规范性,助推我国实验动物科技与比较医学研究的高质量发展。Improving the reproducibility of biomedical research results is a major challenge.Transparent and accurate reporting of the research process enables readers to evaluate the reliability of the research results and further explore the experiment by repeating it or building upon its findings.The ARRIVE 2.0 guidelines,released in 2019 by the UK National Centre for the Replacement,Refinement and Reduction of Animals in Research(NC3Rs),provide a checklist applicable to any in vivo animal research report.These guidelines aim to improve the standardization of experimental design,implementation,and reporting,as well as the reliability,repeatability,and clinical translatability of animal experimental results.The use of ARRIVE 2.0 guidelines not only enriches the details of animal experimental research reports,ensuring that information on animal experimental results is fully evaluated and utilized,but also enables readers to understand the content expressed by the author accurately and clearly,promoting the transparency and integrity of the fundamental research review process.At present,the ARRIVE 2.0 guidelines have been widely adopted by international biomedical journals.This article is a Chinese translation based on the best practices of international journals following the ARRIVE 2.0 guidelines in international journals,specifically for the complete interpretation of the ARRIVE 2.0 guidelines published in the PLoS Biology journal in 2020(original text can be found at https://arriveguidelines.org).The fourth part of the article includes the items 1-5 of ARRIVE 2.0 Recommended 11 section,which covers"Abstract""Background""Objectives""Ethical statement"and"Housing and husbandry".Its aim is to promote the full understanding and use of the ARRIVE 2.0 guidelines by domestic researchers,enhance the standardization of experimental animal research and reporting,and promote the high-quality development of experimental animal technology and comparative medicine research in China.

关 键 词：动物实验 ARRIVE 2.0指南 ARRIVE推荐11条 摘要 研究背景 研究目标 伦理声明 饲养场所和饲养 

分 类 号：R-332[医药卫生] Q95-33[生物学—动物学]