环氧丁烷开环胺解合成β-氨基醇  

Synthesis ofβ-Amino Alcohol by Ring Opening Amination of Epoxybutane

作　　者：孙艳荣 马利国 张志鹏 李赛松 李冬至 申鹏 李双雯 SUN Yanrong;MA Liguo;ZHANG Zhipeng;LI Saisong;LI Dongzhi;SHEN Peng;LI Shuangwen(College of Materials Engineering,Hebei Provincial Key Laboratory of Thermal Protection Materials,North China Institute of Aerospace Engineering,Langfang 065000,China)

机构地区：[1]北华航天工业学院材料工程学院,河北省热防护材料重点实验室,河北廊坊065000

出　　处：《化学反应工程与工艺》2023年第5期470-474,共5页Chemical Reaction Engineering and Technology

基　　金：河北省省级科技计划-中央引导地方科技发展资助项目(216Z1005G)。

摘　　要：为绿色高效地合成β-氨基醇类化合物,本工作以环氧丁烷和戊胺为原料,合成了一种具有大基团的β-氨基醇,并对化合物结构进行了表征。研究发现,环氧丁烷和戊胺可以在去离子水溶剂中高效合成β-氨基醇,当环氧丁烷和戊胺的物质的量比为1:15,在去离子水溶剂体系中室温下反应3 h,β-氨基醇的产率可达87%左右。环氧丁烷在无催化剂情况下的开环胺解合成β-氨基醇过程简便,产物选择性好,是一种合乎“绿色化学”、对环境友好的β-氨基醇制备技术。For green and efficient synthesis ofβ-amino alcohol compounds,aβ-amino alcohol with a large functional group was synthesized using epoxybutane and pentamine as raw materials and its structure was characterized in this paper.It was found that theβ-amino alcohol could be efficiently synthesized by the reaction of epoxybutane and pentamine in deionized water solvent.The yield of theβ-amino alcohol was about 87%when the molar ratio of epoxybutane to pentamine was 1:15 and the reaction was carried out at room temperature in a deionized water solvent system for 3 h.The ring opening aminolysis of epoxybutane toβ-amino alcohol without catalyst was easy to operate and showed good product selectivity,which was an environmentally friendly preparation technology ofβ-amino alcohol belonging to the category of"green chemistry".

关 键 词：环氧丁烷 戊胺 Β-氨基醇 开环胺解 

分 类 号：O643[理学—物理化学]