幽门螺杆菌导致上皮间质转化的研究进展  

Progress in the Study of Epithelial-mesenchymal Transition Caused by Helicobacter Pylori

作　　者：宁月 王蒙 邵利华 焦婷红 李海龙[1,2,4] NING Yue;WANG Meng;SHAO Lihua;JIAO Tinghong;LI Hailong(The First Clinical Medical College of Gansu University of Chinese Medicine,Lanzhou,Gansu Province,730000 China;Key Laboratory of Excavation and Innovative Transformation of Traditional Chinese Medicine,Lanzhou,Gansu Province,730000 China;Clinical Training Department,Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou,Gansu Province,730000 China;Gansu Provincial Engineering Laboratory for the Creation and Manufacture of New Chinese Medicinal Products,Lanzhou,Gansu Province,730000 China)

机构地区：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000 [2]甘肃省中医方药挖掘与创新转化重点实验室,甘肃兰州730000 [3]甘肃中医药大学附属医院临教科,甘肃兰州730000 [4]甘肃省中药新产品创制工程实验室,甘肃兰州730000

出　　处：《系统医学》2023年第19期190-198,共9页Systems Medicine

基　　金：甘肃省自然科学基金项目(20JR5RA189)。

摘　　要：众所周知,幽门螺杆菌(helicobacter pylori,Hp)可以导致胃黏膜病变,产生肠化生,最终形成胃癌。Hp导致的上皮间质转化(epithelial-mesenchymal transition,EMT)在学术界已经受到广泛关注。首先,Hp对EMT促进作用通常是由细胞毒素-相关基因A(cytotoxin-associated gene A,CagA)造成的。作为Hp首要的毒力因子,CagA可以促使Hp通过自噬、炎症、癌症干细胞(cancer stem cells,CSC)等促进EMT形成;其次,EMT的发生也涉及受CagA影响的一些受体及因子,如CD44、程序性细胞死亡因子4(programmed cell death 4,PDCD4)、肿瘤坏死因子α(tumor necrosis factor alpha,TNF-α)。此外,Hp促进EMT还包括某些信号通路发生信号传导改变,目前已知的受调控的通路有NF-κB、TGF-β/Smad、PI3K/AKT通路等。本文尝试对Hp导致EMT的机制做一综述,试图阐明其机制,为Hp防控和相关疾病的治疗提供思路和线索。It is well known that Helicobacter pylori(Hp)can lead to gastric mucosal lesions,intestinal metaplasia and ultimately gastric cancer.Epithelial-mesenchymal transition(EMT)caused by Hp has received extensive attention in academia.Firstly,the EMT-promoting effect of Hp is usually caused by cytotoxin-associated gene A(CagA).As the primary virulence factor of Hp,CagA can prompt Hp to promote EMT formation through autophagy,inflammation,and cancer stem cells(CSC).Secondly,the occurrence of EMT also involves some receptors and factors affected by CagA,such as CD44,programmed cell death 4(PDCD4),and tumor necrosis factor alpha(TNF-α).In addition,the promotion of EMT by Hp also includes signaling alterations in certain signaling pathways,and the known regulated pathways include NF-κB,TGF-β/Smad,and PI3K/AKT pathways.This paper attempts to give an overview of the mechanism of Hp leading to EMT,trying to elucidate the mechanism and provide ideas and clues for the prevention and control of Hp and the treatment of related diseases.

关 键 词：幽门螺杆菌 上皮间质转化 胃癌 肿瘤侵袭和转移 

分 类 号：R735.2[医药卫生—肿瘤]