血清5-羟色胺、基质金属蛋白酶-9与前庭性偏头痛患者认知功能的相关性  

Correlation between serum 5-hydroxytryptamine,matrix metalloproteinase-9,and cognitive function inpatients with vestibular migraine

作　　者：石晶[1] 郑兴月 张磊[1] 杨奉庆 赵莉[1] 闫中瑞[1] Shi Jing;Zheng Xingyue;Zhang Lei;Yang Fengqing;Zhao Li;Yan Zhongrui(Dizziness Center,Jining First People's Hospital&Affiliated Jining First People's Hospital of Shandong FirstMedical University,Jining 272000,China;Spine Surgery,Jining First People's Hospital&Affiliated Jining First People's Hospital of Shandong First Medical University,Jining 272000,China)

机构地区：[1]济宁市第一人民医院,山东第一医科大学附属济宁市第一人民医院眩晕中心,272000 [2]济宁市第一人民医院,山东第一医科大学附属济宁市第一人民医院脊柱外科,272000

出　　处：《神经疾病与精神卫生》2023年第12期859-862,共4页Journal of Neuroscience and Mental Health

基　　金：山东省自然科学基金(ZR2015HL039);山东省医药卫生科技发展计划(202003070583);山东第一医科大学附属济宁市第一人民医院启航科研项目(2021-QMH-007)。

摘　　要：目的探讨前庭性偏头痛(VM)患者认知功能与血清5-羟色胺(5-HT)、基质金属蛋白酶-9(MMP-9)的相关性。方法选取2021年5月至2023年1月于济宁市第一人民医院诊治的60例VM患者为VM组,选取同期于本院体检的60名健康人为对照组。采用简易精神状态检查(MMSE)评估两组受试者的认知功能,比较两组受试者的血清5-HT、MMP-9水平。收集VM患者的发作频次、偏头痛发作持续时间、头晕障碍量表(DHI)评分及视觉模拟评分法(VAS)评分。采用Spearman、Pearson相关和多重线性回归分析VM患者偏头痛发作持续时间、发作频次、DHI评分、VAS评分、血清5-HT、MMP-9水平与MMSE评分的相关性。结果VM组的MMSE评分为(24.33±2.67)分,血清5-HT水平为(335.48±91.52)μg/L,低于对照组的(28.90±1.39)分、(515.12±127.57)μg/L,差异有统计学意义(t=-11.91、-8.86;P<0.001)。VM组的血清MMP-9水平为(58.88±11.32)μg/L,高于对照组的(35.94±7.40)μg/L,差异有统计学意义(t=13.14,P<0.001)。VM患者血清5-HT水平与偏头痛发作持续时间、发作频次呈负相关(r=-0.41、-0.61;P<0.05),与MMSE评分呈正相关(r=0.40,P<0.05);血清MMP-9水平与发作频次呈正相关(r=0.70,P<0.05),与MMSE评分呈负相关(r=-0.47,P<0.05)。多重线性回归分析显示,年龄、MMP-9水平、偏头痛发作持续时间、VAS评分、血清5-HT水平、DHI评分为VM患者认知功能的影响因素(P<0.05)。结论血清5-HT、MMP-9水平与VM患者认知功能存在相关性。Objective To explore the correlation between cognitive function and serum5-hydroxytryptamine(5-HT)and matrix metalloproteinase-9(MMP-9)in patients with vestibular migraine(VM).Methods Sixty VM patients at the Jining First People's Hospital from May 2021 to January 2023 were selectedas the VM group,and 60 healthy individuals who underwent physical examinations during the same period wereselected as the control group.The Mini-Mental State Examination(MMSE)was used to evaluate the cognitivefunction of two groups of subjects,and the serum levels of 5-HT and MMP-9 were compared between the twogroups of subjects.The frequency,duration,Dizziness Handicap Inventory(DHI),and Visual Analogue Scale(VAS)of VM patients were collected.Spearman,Pearson correlation,and multiple linear regression were usedto analyze the correlation between migraine duration,frequency,DHI score,VAS score,serum 5-HT,MMP-9levels,and MMSE score in VM patients.Results The MMSE score of the VM group was(24.33±2.67),and the serum 5-HT level was(335.48±91.52)μg/L,lower than the control group's(28.90±1.39),(515.12±127.57)μg/L,the differences were statistically significant(t=-11.91,-8.86;P<0.001).The serumMMP-9 level in the VM group was(58.88±11.32)μg/L,higher than the control group(35.94±7.40)μg/L,the difference was statistically significant(t=13.14,P<0.001).The serum 5-HT levels in VM patients werenegatively correlated with the duration and frequency of vestibular migraine(r=-0.41,-0.61;P<0.05),andpositively correlated with MMSE scores(r=0.40,P<0.05),with statistically significant differences.Theserum MMP-9 level was positively correlated with the frequency of vestibular migraine(r=0.70,P<0.05),andnegatively correlated with MMSE score(r=-0.47,P<0.05),and the differences were statistically significant.Multiple linear regression analysis showed that age,MMP-9 level,duration of vestibular migraine,VAS score,serum 5-HT level,and DHI score were the influencing factors of cognitive function in VM patients,and thedifferences were statistically signifi

关 键 词：5-羟色胺 基质金属蛋白酶-9 前庭性偏头痛 认知功能 

分 类 号：R747.2[医药卫生—神经病学与精神病学]