累及口腔的IgG4相关疾病研究进展  

Research progress of IgG4-related disease in oral cavity

作　　者：张天玉 江潞[1] ZHANG Tianyu;JIANG Lu(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Oral Medicine,West China Hospital of Stomatology,Sichuan University,Chengd)

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院黏膜病科,四川成都610041

出　　处：《口腔医学》2023年第12期1106-1111,共6页Stomatology

基　　金：国家自然科学基金(82171809);中国医学科学院临床与转化医学研究专项项目(2022-I2M-C&T-B-111)。

摘　　要：IgG4相关疾病(immunoglobulin G4-related disease,IgG4-RD)是一种病因不明的全身性多器官纤维炎性疾病,研究认为B细胞和T细胞的增殖活化及其相互作用在该病的免疫反应及纤维化过程中可能发挥重要作用。IgG4-RD可累及包括口腔在内的多个器官和系统。唾液腺是口腔内最常受累的器官,此外,口腔的其他组织也可被IgG4-RD累及,且临床表现异质,临床准确诊断存在困难。为此,该文检索近年来IgG4-RD累及口腔组织的文献报道,结合最新诊断标准,从流行病学、发病机制、临床表现、诊断与治疗出发作一综述。IgG4-related disease(IgG4-RD)is a systemic multi-organ fibroinflammatory disease of unknown etiology.Studies suggest that the proliferation and activation of B cells,T cells and their crosstalk may play important roles in the immune response and fibrosis process of the disease.IgG4-RD can involve multiple organs and systems including the maxillofacial region.Salivary glands are the most frequently involved organs in the oral cavity.In addition,other tissues in the oral cavity can also be affected,and the clinical manifestations are heterogeneous.It is difficult to make accurate clinical diagnosis.To this end,this article searches literature reports of IgG4RD involving oral tissue in recent years,and reviews the IgG4-RD involving oral cavity from the perspective of epidemiology,pathogenesis,clinical manifestation,diagnosis and treatment,combined with the latest diagnostic criteria.

关 键 词：IgG4相关疾病 口腔 发病机制 诊断 治疗 

分 类 号：R781.9[医药卫生—口腔医学]