生物可降解镁基材料在颅颌面外科的应用及其研究进展  

Applications and research progress of biodegradable magnesium-based materials in craniomaxillofacial surgery

作　　者：常欣楠 刘磊[1] Chang Xinnan;Liu Lei(State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Dept.of Trauma and Orthopedic Wards,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病防治全国重点实验室、国家口腔医学中心、国家口腔疾病临床医学研究中心、四川大学华西口腔医院创伤整形外科,成都610041

出　　处：《国际口腔医学杂志》2024年第1期107-115,共9页International Journal of Stomatology

基　　金：四川省科技计划应用基础研究项目(2020YJ0278)。

摘　　要：作为一种新型骨植入材料,生物可降解镁基材料在颅颌面外科显示出广阔的应用前景。与传统骨植入材料相比,镁具有良好的降解特性、生物相容性、力学特性和成骨特性,其降解产物镁离子具有抗凋亡、抗炎的作用,能够促进骨折和骨缺损部位的愈合。多项研究将生物可降解镁基材料应用于颅颌面部骨内固定、引导骨再生技术、骨替代材料、药物负载、种植体表面涂层等领域,其结果显示该类材料能够为骨愈合提供稳定的支持,并发挥出良好的促进成骨作用。此外,镁在口腔其他领域,如牙组织工程、促进软组织愈合等方面也表现出应用潜能,显示出生物可降解镁基材料具有重要的研究价值。As a new generation of bone-implant materials,biodegradable magnesium-based materials show potential application in craniomaxillofacial surgery.Compared with traditional bone-implant materials,magnesium-based materials have excellent degradability,biocompatibility,mechanical properties,and osteogenic-promoting ability.The degradation of Mg implants leads to the production of magnesium ions,which have antiapoptosis and anti-inflammatory functions.Magnesium ions can also promote the healing of fractures and bone defects.Many studies have applied biodegradable magnesium-based materials to the internal fixation of craniomaxillofacial fractures,bone-substitute applications,guided bone regeneration,drug delivery,and implant surface coating.Results reveal that this kind of materials can provide stable support for bone healing and play a suitable role in osteogenic promoting.Magnesium-based materials also demonstrate potential in other fields,such as dental-tissue engineering and promotion of soft-tissue healing.All these findings indicate the importance of magnesium-based materials.

关 键 词：生物可降解镁基材料 骨内固定 引导骨再生技术 骨替代材料 药物负载 镁涂层 

分 类 号：R782.2[医药卫生—口腔医学]