1%聚桂醇泡沫硬化剂与平阳霉素局部注射治疗婴幼儿血管瘤252例临床分析  

Clinical analysis of the treatment of 252 infantile hemangioma by local injection of 1% lauromacrogol foam and pingyangmycin

作　　者：钱莹莹 钟欣妮 钱华[1] 吴亚芬[1] 张婷[1] 胡翠[1] 鲁慧[1] 李巍[1] QIAN Yingying;ZHONG Xinni;QIAN Hua;WU Yafen;ZHANG Ting;HU Cui;LU Hui;LI Wei(Department of Dermatology,Children’s Hospital of Soochow University,Suzhou 215003,China)

机构地区：[1]苏州大学附属儿童医院皮肤科,江苏苏州215003

出　　处：《临床皮肤科杂志》2024年第1期19-22,共4页Journal of Clinical Dermatology

摘　　要：目的:研究1%聚桂醇泡沫硬化剂与平阳霉素局部注射治疗婴幼儿血管瘤的临床疗效及并发症的差异。方法:回顾性分析2013年11月—2021年12月于苏州大学附属儿童医院皮肤科接受局部注射治疗的252例婴幼儿血管瘤患儿的病例资料。结果:1%聚桂醇泡沫硬化剂组138例患儿,平均治疗次数3.6次,其中治愈78例(56.52%),显效44例(31.88%),有效10例(7.25%),无效6例(4.35%),有效率88.40%。平阳霉素组114例患儿,平均治疗次数4.8次,其中治愈65例(57.02%),显效31例(27.19%),有效12例(10.53%),无效6例(5.26%),有效率84.21%,两组有效率比较差异无统计学意义(P>0.05)。1%聚桂醇泡沫硬化剂组9例(6.52%)出现并发症,其中4例瘤体糜烂、破溃,4例瘤体部位色素减退,1例发热。平阳霉素组24例(21.05%)出现并发症,其中10例患儿发热,2例腹泻,6例瘤体表面破溃、结痂,6例出现局部色素减退。平阳霉素组并发症发生率明显高于1%聚桂醇泡沫硬化剂组,差异具有统计学意义(P<0.05)。结论:1%聚桂醇泡沫硬化剂和平阳霉素局部注射治疗婴幼儿血管瘤均有显著疗效,但1%聚桂醇泡沫硬化剂治疗次数更少,且发生并发症及不良反应更少。提示使用1%聚桂醇泡沫硬化剂治疗婴幼儿血管瘤安全有效,且治疗周期短。Objective:To study the difference of clinical efficacy and complications between 1% lauromacrogol foam and pingyangmycin sclerotherapy in the treatment of infantile hemangioma.Methods:The clinical data of 252 infantile hemangioma patients who received local injection in the dermatology department of Children's Hospital of Soochow University from November 2013to December 2021 were retrospectively analyzed.Results:In the 1% lauromacrogol foam group of 138 children,the average treat ment times were 3.6,78 cases were cured(56.52%),44 cases were markedly effective(31.88%),10 cases were effective(7.25%),6 cases were ineffective(4.35%),and the overall effective rate was 88.40%.There were 114 children in pingyangmycin group,the average treatment times were 4.8,65 cases were cured(57.02%),31 cases were markedly effective(27.19%),12 cases were effective(10.53%),6 cases were ineffective(5.26%),and the overall effective rate was 84.21%.There was no significant difference in the overall effective rate between the two groups(P>0.05).Nine patients(6.52%) in the 1% lauromacrogol foam group developed complications,including 4 patients with erosion and ulceration of the tumor,4 patients with hypopigmentation in the tumor site,and 1 case of fever.In pingyangmycin group,24 cases(21.05%) had complications,including 10 cases of fever,2 cases of diarrhea,6 cases of tumor surface ulceration and scab,and 6 cases of local hypopigmentation.Compared with the two groups,the incidence of complications in pingyangmycin group was significantly higher than that in 1% lauro macrogol foam group,the difference was statistically significant(P<0.05).Conclusion:Both 1% lauromacrogol foam and pingyangmycin local injection have significant efficacy in the treatment of infantile hemangioma,but 1% lauromacrogol foam shows fewer times of treatment,fewer complications or adverse reactions,compared with that seen in pingyangmycin group.The result of this study suggests that 1% lauromacrogol foam injection is safe and effective with short treatment cycle in t

关 键 词：聚桂醇 平阳霉素 婴幼儿血管瘤 局部注射 

分 类 号：R732.2[医药卫生—肿瘤]