Association of symptomatic late-onset hypogonadism and lower urinary tract symptoms in aging males: a community-based study  

作　　者：Guo-Qing Liang Jian-Hui Li Hui-Juan Shi Jun-Biao Zheng Xiao-Hua Yu Shu-Cheng Zhang Zheng Li Qian-Xi Zhu Yu-Xuan Song Feng Jiang Yong Zhu 

机构地区：[1]Obstetrics and Gynecology Hospital,Fudan University,Shanghai 200011,China [2]Department of Reproductive Epidemiology and Social Science,NHC Key Lab of Reproduction Regulation,Shanghai Institute for Biomedical and Pharmaceutical Technologies,Fudan University,Shanghai 200237,China [3]Department of Urology,The First People's Hospital of Jiashan,Zhejiang 314100,China [4]Department of Cell Biology,National Research Institute of Family Planning,Bejing 100081,China [5]Department of Andrology,Shanghai General Hospital,Shanghai Jiao Tong University,Shanghai 200080,China [6]Department of Urology,Peking University People's Hospital,Bejing 100044,China.

出　　处：《Reproductive and Developmental Medicine》2023年第3期129-134,共6页生殖与发育医学（英文版）

摘　　要：Objective:Testosterone deficiency may be a risk factor for lower urinary tract symptoms(LUTS),and there may be a causal ink between the emergence of LUTS and the incidence of late-onset hypogonadism(LOH).We perfomed an epidemiologic study to investigate the association between symptomatic late-onset hypogonadism(SLOH)and LUTS in middle-aged and elderly rural Chinese males.Methods:A total of 965 men completed a questionnaire and underwent a detailed physical examination.The Aging Males'Symptoms(AMS)scale was used to assess SLOH,and the International Prostate Symptom Score(IPSS)questionnaire was used to assess LUTS.Serum reproductive hormone levels of testosterone,sex hormone-binding globulin(SHBG)and luteinizing hormone(LH)were measured.Results:A total of 965 males(mean age:56.34±8.85,range:40-80 years)were recruited for the present study.A total of 20.93%(202/965)were diagnosed with SLOH.A total of 93.16%(899/965)had mild LUTS,5.18%(50/965)had moderate LUTS,and 1.66%(16/965)had severe LUTS.Among SLOH patients,13.40%(27/202)and 3.90%(8/202)had moderate and severe LUTS,respectively.Patients with severe LUTS had increased SHBG and LH compared with those with mild and moderate LUTS(P<0.01).Correlation analysis revealed that the AMS total score was positively correlated with the IPSS score(P<0.05).The prevalence of SLOH was significantly increased with LUTS severity In addition to the known effect of age,the results of mutiple regression analysis also showed that serum LH or SHBG appeared to have a weak link with SLOH and LUTS that requires etiological and biological clarification in our future study.Conclusion:In this cross-sectional analysis of SLOH and LUTS,LUTS severity was significantly associated with hypogonadism symptoms.Additionally,the prevalence of SLOH advanced with increasing LUTS severity.Serum SHBG or LH showed a positive correlation with SLOH and LUTS.

关 键 词：AGING HYPOGONADISM Lower urinary tract symptoms Luteinizing hormone Sex hormone-binding globulin 

分 类 号：R697[医药卫生—泌尿科学]