NMDA受体在偏头痛中作用的研究进展  

Research progress on the role of NMDA receptors in migraine

作　　者：黄亚楠 林亚可 孙婷婷(综述)[1] 潘永惠(审校)[1] HUANG Yanan;LIN Yake;SUN Tingting(The First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院,黑龙江哈尔滨150001

出　　处：《中风与神经疾病杂志》2023年第12期1079-1083,共5页Journal of Apoplexy and Nervous Diseases

基　　金：国家自然科学基金项目(82071549);黑龙江省自然科学基金重点项目(ZD2019H006);黑龙江省教育科学“十三五”规划重点课题(GJB1319086)。

摘　　要：N-甲基-D-天冬氨酸(N-methyl-D-aspartate,NMDA)受体是一种离子型谷氨酸受体,广泛表达于中枢神经系统,介导兴奋性突触传递的Ca2+内流,并在突触可塑性、学习、记忆等方面发挥重要作用。偏头痛是临床常见的原发性头痛,因其发作频繁,给患者带来严重的生活和心理负担。偏头痛的发病机制尚不明确,研究发现,谷氨酸及NMDA受体与偏头痛的发生关系密切。本文主要就NMDA受体与偏头痛的发生,NMDA受体拮抗剂与偏头痛的预防和治疗的相关进展进行综述,旨在为偏头痛的发病机制及药物治疗等提供参考。NmethylD-aspartate(NMDA)receptors are ionotropic glutamate receptors that are widely expressed in the central nervous system.Through mediating Ca2+influx for excitatory synaptic transmission,NMDA receptors play an important role in synaptic plasticity,learning,and memory.Migraine is a common primary headache that brings serious life and mental burdens to patients because of frequent attacks.The pathogenesis of migraine is still unclear.Glutamate and NMDA receptors have been demonstrated to be closely related to the occurrence of migraine.This paper reviews progress on the association of NMDA receptors with migraine and the use of NMDA receptor antagonists for the prevention and treatment of migraine,aiming to provide a reference for the pathogenesis and drug treatment of migraine.

关 键 词：偏头痛 N-甲基-D-天冬氨酸受体 N-甲基-D-天冬氨酸受体拮抗剂 皮质扩散抑制 

分 类 号：R747.2[医药卫生—神经病学与精神病学]