乳腺癌休眠机制研究进展  

Recent Insights into Mechanisms Governing Breast Cancer Dormancy

作　　者：马澜婧 张百红 MA Lanjing;ZHANG Baihong(Department of Oncology,940th Hospital of Joint Logistics Support Force of People’sLiberation Army,Lanzhou 730050,China)

机构地区：[1]中国人民解放军联勤保障部队第940医院肿瘤科,兰州730050

出　　处：《肿瘤防治研究》2023年第12期1237-1242,共6页Cancer Research on Prevention and Treatment

基　　金：甘肃省青年科技基金计划(22JR5RA021)。

摘　　要：肿瘤休眠指的是播散的癌细胞在较长时间内保持存活但不增殖状态。不幸的是,休眠细胞最终会“苏醒”,恢复增殖并产生明显的转移。由于晚期复发与肿瘤休眠之间的密切关系,癌症的休眠机制尤其受到关注。在这篇综述中,我们介绍了乳腺癌休眠生物学基础的最新发现,为临床医生提供乳腺癌休眠的概述。Tumor dormancy refers to the status of disseminated cancer cells that remain in a viable yet not proliferating state for a prolonged period.Dormant cells will eventually“re-awake”resume their proliferation,and produce overt metastasis.The dormancy mechanism of cancer has attracted attention because of the close relationship between late recurrence and tumor dormancy.In this review,we illustrate the latest discoveries on the biological underpinnings of breast cancer dormancy and offer clinicians an overview of dormancy in breast cancer to guide them in the basic understanding of the complexity that underlies this process.

关 键 词：乳腺癌 肿瘤休眠 自噬 免疫逃逸 表观遗传 代谢重编程 肿瘤微环境 非编码RNA 

分 类 号：R737.9[医药卫生—肿瘤]