子宫内膜癌相关生物标志物研究现状  

Advances in endometrial cancer-related biomarker research

作　　者：王璐[1] 樊杨[2] Wang Lu;Fan Yang(Third Clinical Medical College,Ningxia Medical University,Yinchuan 750016,Ningxia Hui Autonomous Region,China;Department of Obstetrics and Gynecology,People′s Hospital of Ningxia Hui Autonomous Region,Yinchuan 750016,Ningxia Hui Autonomous Region,China)

机构地区：[1]宁夏医科大学第三临床医学院,银川750016 [2]宁夏回族自治区人民医院妇产科,银川750016

出　　处：《中华妇幼临床医学杂志（电子版）》2023年第5期511-516,共6页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：宁夏回族自治区重点研发计划项目(2022BEG01003)。

摘　　要：分子遗传学机制在子宫内膜癌(EC)患者临床诊疗中的重要性日益凸显。EC患者的分子分型,可有效预测其预后及指导临床治疗。2013年,美国癌症基因组图谱(TCGA)项目拉开了EC分子分型诊疗序幕。2020年,世界卫生组织(WHO)颁布《女性生殖系统肿瘤分类(5版)》在EC患者分子分型中,将分子遗传学特征整合到病理形态学分型中。2021年,我国首次将EC的分子分型,纳入我国制定的临床指南中。基于EC患者分子分型的相关分子生物标志物研究,也正在进行中,许多新的EC诊治相关生物标志物不断被发现。但是,针对EC患者的诊疗,当前尚无常规应用的分子生物标志物,而且当前的EC分子分型方法多,临床上尚不统一。笔者拟就EC患者基因、蛋白及激素相关分子生物标志物的最新研究现状进行阐述,旨在为该领域相关研究提供参考。Molecular genetic mechanisms are increasingly important in the clinical management of endometrial carcinoma(EC),and molecular typing can effectively predict prognosis and guide treatment.In 2013,it is the start of the US Cancer Genome Atlas project that kicked off the molecular management of EC.In 2020,the Classification of Tumours of the Female Reproductive System(5th edition)issued by the World Health Organization(WHO)integrates molecular genetic features into the pathomorphological typing of EC.In 2021,for the first time in China,molecular staging of endometrial cancer was included in the guidelines.At the same time,researches on biomarkers based on molecular typing is ongoing,and many new biomarkers are being discovered.However,there are currently no routinely applied molecular markers for EC diagnosis and treatment,and the current methods of EC staging are multiple and not yet uniform.We intend to describe the latest status of researches on genes,proteins and hormone-related molecular biomarkers in EC patients,with the aim of providing a reference for relevant research in this field.

关 键 词：子宫内膜肿瘤 生物学标记 肿瘤 诊断技术和方法 预后 生殖系统肿瘤 分子靶向治疗 围绝经期和绝经后女性 

分 类 号：R737.33[医药卫生—肿瘤]