首发精神分裂症患者血清肥胖抑制素、摄食抑制因子1水平及临床意义  

Serum obestatin and nesfatin-1 levels in patients with first episode schizophrenia and their clinical significance

作　　者：乐亚娟 沈悦 蔡丽丽 王振华[1] LE Yajuan;SHEN Yue;CAI Lili;WANG Zhenhua(Department of Psychiatry,Huzhou Third People's Hospital,Huzhou 313000,China)

机构地区：[1]湖州市第三人民医院精神科,浙江湖州313000

出　　处：《温州医科大学学报》2024年第1期25-30,共6页Journal of Wenzhou Medical University

基　　金：浙江省医药卫生科技计划项目(2022KY1225)。

摘　　要：目的:探究首发精神分裂症患者血清肥胖抑制素(obestatin)、摄食抑制因子1(nesfatin-1)水平与认知功能的关系。方法:选取2018年6月至2021年6月湖州市第三人民医院收治的98例经确诊的首发精神分裂症患者作为患者组,另选取同期社会健康志愿者102例为对照组。采用酶联免疫吸附(ELISA)法检测首发精神分裂症患者血清中obestatin、nesfatin-1水平。采用阳性与阴性症状量表(PANSS)评估患者的临床症状,选取认知功能成套测验-共识版(MCCB)中的连线测验(TMT)、简易视觉空间记忆测验-修订版(BVMT-R)、霍普金斯词汇学习测验-修订版(HVLT-R)、精神分裂症符号编码认知评估(BACS SC)、神经心理学评估(NAB)、持续操作测验-相同配对(CPT-IP)这六个项目评估患者的认知功能。结果:患者组血清nesfatin-1水平以及TMT评分明显高于对照组,obestatin水平、BVMT-R、HVLT-R、BACS SC、NAB、CPT-IP评分显著低于对照组(P<0.05)。Pearson相关性分析结果表明,首发精神分裂症患者血清中nesfatin-1表达与PANSS总分呈显著正相关(r=0.486,P<0.05),obestatin表达与PANSS总分呈显著负相关(r=-0.422,P<0.05);患者血清中nesfatin-1水平与HVLT-R、NAB评分呈负相关关系(r=-0.501、-0.545,P<0.05),obestatin水平与HVLT-R、NAB评分呈正相关关系(r=0.435、0.491,P<0.05)。多因素Logistic回归分析结果显示,NAB评分(OR=1.541,95%CI=1.131~2.100,P=0.006)、obestatin(OR=1.713,95%CI=1.247~2.353,P=0.001)和nesfatin-1水平(OR=1.647,95%CI=1.213~2.236,P=0.001)是首发精神分裂症发生的影响因素。结论:首发精神分裂症患者血清中obestatin表达水平显著降低,nesfatin-1表达水平显著升高,其与患者的认知功能密切相关。Objective:To explore the relationship between serum obestatin and nesfatin-1 levels with cognitive function in patients with first-episode schizophrenia.Methods:A total of 98 patients diagnosed with first-episode schizophrenia who were admitted to Huzhou Third People's Hospital from June 2018 to June 2021were assigned as the patient group,and 102 healthy volunteers in the same period were selected as the control group.The serum levels of Obestatin and nesfatin-1 in patients with first-episode schizophrenia were detected by enzyme-linked immunosorbent assay(ELISA).Clinical symptoms were assessed using the positive and negative syndrome scale(PANSS),the trail-making test(TMT),brief visuospatial memory test-revised(BVMT-R),Hopkins verbal learning test-revised(HVLT-R),brief assessment of cognition in schizophrenia-symbol coding(BACS SC),neuropsychological assessment battery(NAB),continuous performance test-identical pairs(CPT-IP) in the MATRICS consensus cognitive battery(MCCB) were used to evaluate the cognitive function of patients.Results:The serum nesfatin-1 level and TMT score in the patient group were obviously higher than those in the control group,the obestatin level,BVMT-R,HVLT-R,BACS SC,NAB and CPT-IP scores were obviously lower than those in the control group(P<0.05).Pearson's correlation analysis showed that the expression of nesfatin-1 in the serum of patients with first-episode schizophrenia was obviously positively correlated with the total score of PANSS(r=0.486,P<0.05);the expression of obestatin was obviously negatively correlated with the total score of PANSS(r=-0.422,P<0.05);the level of serum nesfatin-1 was negatively correlated with HVLTR and NAB scores(r=-0.501,-0.545,P<0.05),and the level of obestatin was positively correlated with HVLTR and NAB scores(r=0.435,0.491,P<0.05).Multivariate logistic regression analysis showed that NAB score(OR=1.541,95%CI=1.131-2.100,P=0.006),obestatin(OR=1.713,95%CI=1.247-2.353,P=0.001) and nesfatin-1 levels(OR=1.647,95%CI=1.213-2.236,P=0.001) were the factors af

关 键 词：首发精神分裂症 肥胖抑制素 摄食抑制因子1 认知功能 

分 类 号：R749[医药卫生—神经病学与精神病学]