外周血PD-1、CTLA-4、T-reg、pDC与鼻咽癌患者临床特征及疗效的相关性  

Correlation of peripheral blood PD-1,CTLA-4,T-reg,pDC with clinical characteristics and efficacy of nasopharyngeal carcinoma

作　　者：徐歆宇 赵朝芬 贺前勇 刘丽娜 王伟 邵春燕 熊伟 金风 XU Xinyu;ZHAO Chaofen;HE Qianyong;LIU Lina;WANG Wei;SHAO Chunyan;XIONG Wei;JIN Feng(Department of Oncology,Affiliated Hospital of Guizhou Medical University,Guizhou Guiyang 550004,China;Department of Oncology,Affiliated Cancer Hospital of Guizhou Medical University,Guizhou Guiyang 550008,China;Department of Oncology,School of Clinical Medicine,Guizhou Medical University,Guizhou Guiyang 550004,China;Department of Clinical Laboratory,Affiliated Cancer Hospital of Guizhou Medical University,Guizhou Guiyang 550008,China)

机构地区：[1]贵州医科大学附属医院肿瘤科,贵州贵阳550004 [2]贵州医科大学附属肿瘤医院肿瘤科,贵州贵阳550004 [3]贵州医科大学临床医学院肿瘤学教研室,贵州贵阳550004 [4]贵州医科大学附属肿瘤医院检验科,贵州贵阳550004

出　　处：《现代肿瘤医学》2024年第1期53-60,共8页Journal of Modern Oncology

基　　金：国家自然科学基金计划项目(编号:82060556);贵州省卫生健康委科学技术基金项目(编号:gzwkj2022-020);贵州省科技计划项目[编号:黔科合成果-LC(2023)029]。

摘　　要：目的:探讨初治鼻咽癌患者治疗前外周血PD-1/CTL(%)、CTLA-4/CTL(%)、T-reg(%)、pDC与患者临床特征及即刻疗效的关系,以及以上指标在鼻咽癌患者及健康人群中的表达差异。方法:收集112例初治鼻咽癌患者治疗前临床资料及淋巴细胞亚群和树突细胞亚群数据,进行外周血PD-1/CTL(%)、CTLA-4/CTL(%)、T-reg(%)、pDC与鼻咽癌患者临床特征及即刻疗效的相关性分析,从112例鼻咽癌患者中随机选取30例患者作为病例组,年龄、性别匹配的30例同期体检健康者作为对照组,分析两组外周血PD-1/CTL(%)、CTLA-4/CTL(%)、T-reg(%)、pDC表达差异。结果:112例初治鼻咽癌患者中,年龄≥50岁组与年龄<50岁组相比,外周血PD-1/CTL(%)更高。CTLA-4/CTL(%)与T分期、N分期、TNM分期呈负相关,CTLA-4/CT(%)越高,疗效越好。T-reg(%)与N分期呈正相关,T-reg(%)与M分期存在“S”型曲线关系。pDC与N分期、TNM分期呈负相关。病例组与对照组外周血PD-1/CTL(%)、T-reg(%)差异存在统计学意义,病例组与对照组外周血CTLA-4/CTL(%)差异不存在统计学意义。结论:外周血CTLA-4/CT(%)越高,鼻咽癌T分期、N分期、TNM分期越早,外周血CTLA-4/CT(%)越高,疗效越好。外周血T-reg(%)越高,N分期越晚。当外周血T-reg(%)<20%时,鼻咽癌可能未发生远处转移,当外周血T-reg(%)为20%~50%时,外周血T-reg(%)表达越高,发生远处转移的可能越大,当外周血T-reg(%)>50%时,鼻咽癌已经远处转移的可能性大。外周血pDC越高,N分期、TNM分期越早。外周血以上指标可动态观察,有望成为预测鼻咽癌患者疗效及预后的生物标志物。Objective:To explore the relationship between peripheral blood PD-1/CTL(%),CTLA-4/CTL(%),T-reg(%),pDC and the clinical characteristics and immediate curative effect of nasopharyngeal carcinoma in patients with primary treatment of nasopharyngeal carcinoma before treatment,as well as the expression difference in patients with nasopharyngeal carcinoma and healthy people.Methods:The clinical data,lymphocyte subsets and dendritic cell subsets of 112 patients with initially treated nasopharyngeal carcinoma were collected before treatment,and the correlation between peripheral blood PD-1/CTL(%),CTLA-4/CTL(%),T-reg(%),pDC and the clinical characteristics and immediate efficacy of nasopharyngeal carcinoma was analyzed.In 112 patients with nasopharyngeal carcinoma,30 patients were randomly selected as the case group,and 30 healthy patients matched in age and gender were selected as the control group.The expression differences of PD-1/CTL(%),CTLA-4/CTL(%),T-reg(%) and pDC in peripheral blood of the two groups were analyzed.Results:Among 112 patients with nasopharyngeal carcinoma treated for the first time,PD-1/CTL(%) in peripheral blood of ≥50 years old group was higher than that of < 50 years old group.CTLA-4/CTL(%) was negatively correlated with T stage,N stage and TNM stage.The higher the CTLA-4/CT(%),the better the therapeutic effect.T-reg(%) was positively correlated with N staging.T-reg(%) had an S-type curve relationship with M stage.pDC was negatively correlated with N stage and TNM stage.There was statistical significance in PD-1/CTL(%) and T-reg(%) of peripheral blood between the case group and the control group,while there was no statistical significance in CTLA-4/CTL(%) of peripheral blood between the case group and the control group.Conclusion:The higher the peripheral blood CTLA-4/CT(%),the earlier the T stage,N stage and TNM stage of nasopharyngeal carcinoma.The higher the peripheral blood CTLA-4/CT(%),the better the curative effect.The higher the T-reg(%) in peripheral blood,the later the N stage.When per

关 键 词：鼻咽癌 临床特征 即刻疗效 PD-1 CTLA-4 T-reg PDC 

分 类 号：R739.62[医药卫生—肿瘤]