黏蛋白型O⁃糖基化与结直肠癌基础和临床研究进展  

Progress of Basic and Clinical Research on Mucin⁃type O⁃Glycosylation and Colorectal Cancer

作　　者：汪泽慧 张军[1] WANG Zehui;ZHANG Jun(Department of Gastroenterology,Nanjing Hospital Affiliated to Nanjing Medical University,Nanjing 210006)

机构地区：[1]南京医科大学附属南京医院消化内科,210006

出　　处：《胃肠病学》2023年第3期181-185,共5页Chinese Journal of Gastroenterology

摘　　要：O⁃糖基化为黏蛋白常见的翻译后修饰,普遍存在于正常细胞和肿瘤细胞中。结直肠癌(CRC)细胞内O⁃糖基化相关的糖基转移酶、分子伴侣和表面的Tn抗原、sTn抗原、T抗原出现不同程度的失调,且以其特有方式参与CRC的发生、发展,包括侵袭和转移、异常凋亡和增殖、免疫逃逸等,并作为新型肿瘤生物学标志物和潜在治疗靶点被广泛研究。本文就黏蛋白型O⁃糖基化与CRC的发生、发展及其临床应用的研究进展作一综述。O⁃glycosylation is a common post⁃translational modification of mucins,widely present in both normal and tumor cells.In colorectal cancer(CRC)cells,there is a varying degree of dysregulation in O⁃glycosylation⁃related glycosyltransferases,molecular chaperones,and surface Tn antigen,sTn antigen,and T antigen.These dysregulations play a distinctive role in the occurrence and development of CRC,including invasion and metastasis,abnormal apoptosis and proliferation,immune escape,etc.They are extensively studied as novel tumor biomarkers and potential therapeutic targets.This article provides a comprehensive review of progress of research on mucin⁃type O⁃glycosylation and its relevance to the occurrence and development of CRC and its clinical application.

关 键 词：黏蛋白型O⁃糖基化 结直肠肿瘤 糖基转移酶类 STN抗原 

分 类 号：R735.34[医药卫生—肿瘤]