低剂量头颈CTA及全脑CTP技术在颈动脉源性脑灌注异常评估中的应用  

Application of low-dose head/neck CT angiography and whole brain CT perfusion in carotidassociated cerebral perfusion abnormalities

作　　者：蔡培坤[1] 陈杰彬[1] 蔡勇[1] 梁焕[1] 梁晖辉[1] 李冲云[1] 陈晓波[1] 陈潇豫 CAI Pei-kun;CHEN Jie-bin;CAI Yong;LIANG Huan;LIANG Hui-hui;LI Chong-yun;CHEN Xiao-bo;CHEN Xiaoyu(Department of Radiology,Maoming People’s Hospital,Maoming 525000,China)

机构地区：[1]广东省茂名市人民医院放射科,广东茂名525000

出　　处：《广东医科大学学报》2023年第6期631-635,共5页Journal of Guangdong Medical University

基　　金：广东省茂名市科技计划项目(2022203)。

摘　　要：目的探究低剂量头颈计算机断层扫描血管成像(CTA)及全脑计算机断层扫描灌注成像(CTP)技术在脑灌注评估中的应用。方法86例超声检查提示颈动脉狭窄患者、50例健康体检者进行CTA和CTP检查,比较脑灌注参数[脑血流量(CBF)、脑血容量(CBV)、平均通过时间(MTT)和达峰时间(TTP)]及CTP参数异常脑功能区分布。结果狭窄组前循环供血动脉CBF、CBV均小于对照组(P<0.01),MTT、TTP均大于对照组(P<0.01)。随着狭窄程度加重,全脑CBF、CBV、MTT、TTP异常区域占全脑容量的百分比明显增加(P<0.01)。结论低剂量头颈CTA及全脑CTP技术在颈动脉源性脑灌注异常的评估中具有重要价值。Objective To study the application of low-dose head/neck computed tomography angiography(CTA)and whole brain computed tomography perfusion(CTP)in cerebral perfusion.Methods Eighty-six patients with ultrasounddiagnosed carotid artery stenosis(stenosis group)and 50 healthy subjects(control group)underwent low-dose head/neck CTA and whole brain CTP.The cerebral perfusion parameters including cerebral blood flow(CBF),cerebral blood volume(CBV),mean transit time(MTT)and time to peak(TTP),and distribution of brain functional regions of abnormal CTP parameters were compared between two groups.Results Compared with control group,CBF and CBV in the anterior circulation were lower,while MTT and TTP were higher(P<0.01)in stenosis group.The percentages of abnormal CBF,CBV,MTT and TTP regions in the whole brain volume were increased with the aggravation of carotid artery stenosis(P<0.01).Conclusion Low-dose head/neck CTA and whole brain CTP can be valuable for carotid-associated cerebral perfusion abnormalities.

关 键 词：计算机断层扫描血管成像 计算机断层扫描灌注成像 颈动脉狭窄 

分 类 号：R743[医药卫生—神经病学与精神病学]