奥美拉唑联合组织胶对乙肝肝硬化EGVB的疗效  

Effect of omeprazole combined with tissue glue on EGVB in hepatitis B cirrhosis

作　　者：田秋红 胡月鹏 江小红 康晓峰 TIAN Qiu-hong;HU Yue-peng;JIANG Xiao-hong(Yudu County People's Hospital,Yudu 342300,Jiangxi)

机构地区：[1]于都县人民医院,江西于都342300

出　　处：《安徽医专学报》2023年第6期43-45,共3页Journal of Anhui Medical College

基　　金：赣州市指导性科技计划项目(编号:GZ2021ZSF623)。

摘　　要：目目的:探讨乙肝肝硬化并食管胃底静脉曲张破裂出血(EGVB)患者治疗时联合奥美拉唑与胃镜下注射组织胶的效果。方法:选择医院消化内科收治的乙型肝炎肝硬化合并食管胃底静脉曲张破裂出血患者60例,随机分为实验组和对照组,各30例。比较两组患者血流变、止血效果、静脉曲张消失率、治疗48h再出血率、并发症发生率及疾病复发率。结果:治疗7d后,两组患者HSV、LSV、PV均上升,且实验组患者比对照组患者高(P<0.05);实验组患者止血时间及住院时间比对照组短,差异有统计学意义(P<0.05);实验组患者的止血总有效率、静脉曲张消失率高于对照组,差异有统计学意义(P<0.05);实验组患者的输血量、早期再出血率、并发症发生率、疾病复发率低于对照组患者,差异有统计学意义(P<0.05)。结论:乙型肝炎肝硬化合并食管胃底静脉曲张破裂出血患者治疗时联合奥美拉唑与胃镜下注射组织胶,止血效果理想,可改善血流变指标,降低输血量、早期再出血率及并发症发生率,改善预后。Objective:To investigate the effect of omeprazole combined with gastroscopic injection of tissue glue in the treatment of patients with liver cirrhosis and esophagogastric variceal hemorrhage(EGVB).Methods:60 patients with hepatitis B cirrhosis complicated with esophageal and gastric varices bleeding admitted to the Hospital were randomly divided into an experimental group and a control group with 30 cases in each according to the blind method of binocular random selection.Compare the hemorheology,hemostatic effect,disappearance rate of varicose veins,bleeding rate after 48 hours of treatment,incidence of complications,and disease recurrence rate between the two groups of patients.Result:After 7 days of treatment,HSV,LSV,and PV increased in both groups,and the experimental group patients were higher than the control group patients(P<0.05);The hemostasis time and hospitalization time of the experimental group patients were shorter than those of the control group,and the difference was statistically significant(P<0.05);The total effective rate of hemostasis and the disappearance rate of varicose veins in the experimental group were higher than those in the control group,and the difference was statistically significant(P<0.05);The blood transfusion volume,early rebleeding rate,complication incidence,and disease recurrence rate of the experimental group patients were lower than those of the control group patients,and the difference was statistically significant(P<0.05).Conclusion:The combination of Omeprazole and injection of tissue glue under gastroscope in the treatment of patients with hepatitis B cirrhosis complicated with esophageal and gastric varices bleeding has ideal hemostatic effect,which can improve hemorheological indexes,reduce blood transfusion volume,early rebleeding rate and complication rate,and improve long-term prognosis.

关 键 词：乙型肝炎肝硬化 食管胃底静脉曲张破裂出血 奥美拉唑 胃镜下注射组织胶 

分 类 号：R575.2[医药卫生—消化系统]